(E)-methyl 1-(5-chloro-2-(4-chloro-2-fluorostyryl)benzyl)-1H-indole-4-carboxylate

Base Information

Chemical Name:(E)-methyl 1-(5-chloro-2-(4-chloro-2-fluorostyryl)benzyl)-1H-indole-4-carboxylate
CAS No.:1427423-19-5
Molecular Formula:C₂₅H₁₈Cl₂FNO₂
Molecular Weight:454.328
Hs Code.:

Synonyms:(E)-methyl 1-(5-chloro-2-(4-chloro-2-fluorostyryl)benzyl)-1H-indole-4-carboxylate

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Chemical Property of (E)-methyl 1-(5-chloro-2-(4-chloro-2-fluorostyryl)benzyl)-1H-indole-4-carboxylate

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Technology Process of (E)-methyl 1-(5-chloro-2-(4-chloro-2-fluorostyryl)benzyl)-1H-indole-4-carboxylate

There total 4 articles about (E)-methyl 1-(5-chloro-2-(4-chloro-2-fluorostyryl)benzyl)-1H-indole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 39830-66-5
methyl 1H-indole-4-carboxylate

: 1427423-17-3
(E)-2-(bromomethyl)-4-chloro-1-(4-chloro-2-fluorostyryl)benzene

: 1427423-19-5
(E)-methyl 1-(5-chloro-2-(4-chloro-2-fluorostyryl)benzyl)-1H-indole-4-carboxylate

Guidance literature:: methyl 1H-indole-4-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

(E)-2-(bromomethyl)-4-chloro-1-(4-chloro-2-fluorostyryl)benzene; In N,N-dimethyl-formamide; mineral oil;

Reference yield: 85.0%

: 1427423-17-3
(E)-2-(bromomethyl)-4-chloro-1-(4-chloro-2-fluorostyryl)benzene

: 7-fluoro-1H-indole-4-carboxylic acid methyl ester

: 1427423-19-5
(E)-methyl 1-(5-chloro-2-(4-chloro-2-fluorostyryl)benzyl)-1H-indole-4-carboxylate

Guidance literature:: 7-fluoro-1H-indole-4-carboxylic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

(E)-2-(bromomethyl)-4-chloro-1-(4-chloro-2-fluorostyryl)benzene; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1427423-19-5
(E)-methyl 1-(5-chloro-2-(4-chloro-2-fluorostyryl)benzyl)-1H-indole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 1.5 h / -40 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 100 °C / 18751.9 Torr / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;