2-(tert-butyldimethylsilanyloxy)-5-methoxybenzyl vinyl ether

Base Information

• Chemical Name: 2-(tert-butyldimethylsilanyloxy)-5-methoxybenzyl vinyl ether
• CAS No.: 736985-97-0
• Molecular Formula: C₁₆H₂₆O₃Si
• Molecular Weight: 294.466
• Mol file: 736985-97-0.mol

Synonyms:2-(tert-butyldimethylsilanyloxy)-5-methoxybenzyl vinyl ether

Chemical Property of 2-(tert-butyldimethylsilanyloxy)-5-methoxybenzyl vinyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butyldimethylsilanyloxy)-5-methoxybenzyl vinyl ether

There total 4 articles about 2-(tert-butyldimethylsilanyloxy)-5-methoxybenzyl vinyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethyl vinyl ether (109-92-2,25104-37-4) + (2-((tert-butyldimethylsilyl)oxy)-5-methoxyphenyl)methanol (736985-95-8) → 2-(tert-butyldimethylsilanyloxy)-5-methoxybenzyl vinyl ether (736985-97-0)

Guidance literature:

With mercury(II) diacetate; at 90 ℃; for 32h;

DOI:10.1002/chem.200305629

Reference yield:

2-hydroxy-5-methoxybenzaldehyde (672-13-9) → 2-(tert-butyldimethylsilanyloxy)-5-methoxybenzyl vinyl ether (736985-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / (i-Pr)2NEt / dimethylformamide / 0.5 h / 20 °C

2: 91 percent / NaBH₄ / ethanol / 0.75 h / 0 °C

3: 72 percent / Hg(OAc)2 / 32 h / 90 °C

With sodium tetrahydroborate; mercury(II) diacetate; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/chem.200305629

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 2-(tert-butyldimethylsilanyloxy)-5-methoxybenzyl vinyl ether (736985-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / (i-Pr)2NEt / dimethylformamide / 0.5 h / 20 °C

2: 91 percent / NaBH₄ / ethanol / 0.75 h / 0 °C

3: 72 percent / Hg(OAc)2 / 32 h / 90 °C

With sodium tetrahydroborate; mercury(II) diacetate; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/chem.200305629

upstream raw materials:

ethyl vinyl ether

(2-((tert-butyldimethylsilyl)oxy)-5-methoxyphenyl)methanol

2-hydroxy-5-methoxybenzaldehyde

tert-butyldimethylsilyl chloride

Downstream raw materials:

2-hydroxy-5-methoxybenzyl vinyl ether