(S)-2-[(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-propionic acid ethyl ester

Base Information

Chemical Name:(S)-2-[(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-propionic acid ethyl ester
CAS No.:212118-70-2
Molecular Formula:C₁₇H₂₅NO₂
Molecular Weight:275.391
Hs Code.:

Synonyms:(S)-2-[(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-propionic acid ethyl ester

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Chemical Property of (S)-2-[(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-propionic acid ethyl ester

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Technology Process of (S)-2-[(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-propionic acid ethyl ester

There total 1 articles about (S)-2-[(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-acetic acid ethyl ester

: 74-88-4
methyl iodide

: 212118-70-2
(S)-2-[(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-propionic acid ethyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃;
DOI:10.1016/S0040-4039(98)01040-5

Reference yield:

: 212118-70-2
(S)-2-[(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-propionic acid ethyl ester

: 288373-07-9
(S)-2-[(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-propan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h;
DOI:10.1021/jo000080p

Reference yield:

: 212118-70-2
(S)-2-[(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-propionic acid ethyl ester

: (S)-1-{4-Benzyloxy-1-[1-(toluene-4-sulfonyl)-meth-(E)-ylidene]-butyl}-2-((S)-2-chloro-1-methyl-ethyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 4.944 g / LiAlH₄ / diethyl ether / 1 h / 20 °C

2: 2.52 g / H₂ / 10percent Pd-C / ethanol / 144 h / 20 °C / 760.05 Torr

3: 70 percent / HCl; SOCl₂ / CHCl₃ / 3 h / Heating

4: KOH / H₂O

5: CH₂Cl₂ / 24 h / 20 °C

With hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; 10percent Pd-C; In diethyl ether; ethanol; dichloromethane; chloroform; water; 1: Reduction / 2: dealkylation / 3: Chlorination / 4: exchange / 5: Addition;
DOI:10.1021/jo000080p