2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}uridine

Base Information

Chemical Name:2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}uridine
CAS No.:213548-88-0
Molecular Formula:C₂₇H₂₈FN₃O₁₂
Molecular Weight:605.531
Hs Code.:

Synonyms:2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}uridine

Suppliers and Price of 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}uridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}uridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}uridine

There total 8 articles about 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 2'-O-(1-{3-fluoro-4-[2-(4-nitrophenyl)ethoxycarbonyloxy]benzyloxy}ethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 213548-88-0
2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}uridine

Guidance literature:: With Bu₃NF*3H₂O; acetic acid; In 1,4-dioxane; Ambient temperature;
DOI:10.1002/hlca.19980810557

Reference yield: 89.0%

: 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 213548-88-0
2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}uridine

Guidance literature:: DOI:10.1002/1522-2675(20010516)84:5<1066::AID-HLCA1066>3.0.CO;2-H

Reference yield:

: 367-12-4
2-fluorophenol

: 213548-88-0
2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}uridine

Guidance literature:: Multi-step reaction with 6 steps

1: 36 percent / 20percent KOH / H₂O / 6 h / 60 °C

2: 95 percent / pyridine / 6 h / Ambient temperature

3: 1.) DMAP, 2.) p-TsOH / 1.) toluene, CH₃CN, RT, 2.) MeOH, CHCl₃, RT

4: 87 percent / mercury(II)trifluoroacetate / 1 h / Ambient temperature

5: 77 percent / TsOH / toluene / 60 h / 20 °C

6: 89 percent / 0.16M Bu₃NF*3H₂O, AcOH / dioxane / Ambient temperature

With pyridine; dmap; potassium hydroxide; Bu₃NF*3H₂O; mercury(II) trifluoroacetate; toluene-4-sulfonic acid; acetic acid; In 1,4-dioxane; water; toluene;
DOI:10.1002/hlca.19980810557