(3S,4S)-Methyl 5-Cyclohexyl-3-(dimethylphenylsilyl)-4-phthalimidopentanoate

Base Information

Chemical Name:(3S,4S)-Methyl 5-Cyclohexyl-3-(dimethylphenylsilyl)-4-phthalimidopentanoate
CAS No.:131973-33-6
Molecular Formula:C₂₈H₃₅NO₄Si
Molecular Weight:477.676
Hs Code.:

Synonyms:(3S,4S)-Methyl 5-Cyclohexyl-3-(dimethylphenylsilyl)-4-phthalimidopentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4S)-Methyl 5-Cyclohexyl-3-(dimethylphenylsilyl)-4-phthalimidopentanoate

Chemical Property:

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Technology Process of (3S,4S)-Methyl 5-Cyclohexyl-3-(dimethylphenylsilyl)-4-phthalimidopentanoate

There total 5 articles about (3S,4S)-Methyl 5-Cyclohexyl-3-(dimethylphenylsilyl)-4-phthalimidopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 3839-31-4
dimethyl(phenyl)silyllithium

: 131934-01-5
(4S)-(E)-Methyl 5-Cyclohexyl-4-phthalimidopent-2-enoate

: 131973-33-6
(3S,4S)-Methyl 5-Cyclohexyl-3-(dimethylphenylsilyl)-4-phthalimidopentanoate

Guidance literature:: With CuCN; In tetrahydrofuran; 1) -78 deg C, 30 min, 2) -23 deg C, overnight, 3) 0 deg C, 2 h;
DOI:10.1021/jo00006a017

Reference yield:

: 3839-31-4
dimethyl(phenyl)silyllithium

: 131934-01-5
(4S)-(E)-Methyl 5-Cyclohexyl-4-phthalimidopent-2-enoate

: 131934-04-8
(3R,4S)-Methyl 5-Cyclohexyl-3-(dimethylphenylsilyl)-4-phthalimidopentanoate

: 131973-33-6
(3S,4S)-Methyl 5-Cyclohexyl-3-(dimethylphenylsilyl)-4-phthalimidopentanoate

Guidance literature:: With CuCN; In tetrahydrofuran; at 0 ℃;
DOI:10.1021/jo00006a017

Reference yield:

: 136918-14-4,85-41-6
phthalimide

: 131973-33-6
(3S,4S)-Methyl 5-Cyclohexyl-3-(dimethylphenylsilyl)-4-phthalimidopentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 21 h / 25 °C

2: CuCN / tetrahydrofuran / 0 °C

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1021/jo00006a017