2-[4-amino-3-(2,2,2-trifluoroethoxy)phenyl]-3-cyclobutylpropionic acid methyl ester

Base Information

Chemical Name:2-[4-amino-3-(2,2,2-trifluoroethoxy)phenyl]-3-cyclobutylpropionic acid methyl ester
CAS No.:1168134-08-4
Molecular Formula:C₁₆H₂₀F₃NO₃
Molecular Weight:331.335
Hs Code.:

Synonyms:2-[4-amino-3-(2,2,2-trifluoroethoxy)phenyl]-3-cyclobutylpropionic acid methyl ester

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Chemical Property of 2-[4-amino-3-(2,2,2-trifluoroethoxy)phenyl]-3-cyclobutylpropionic acid methyl ester

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Technology Process of 2-[4-amino-3-(2,2,2-trifluoroethoxy)phenyl]-3-cyclobutylpropionic acid methyl ester

There total 5 articles about 2-[4-amino-3-(2,2,2-trifluoroethoxy)phenyl]-3-cyclobutylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1168134-07-3
3-cyclobutyl-2-[4-nitro-3-(2,2,2-trifluoroethoxy)phenyl]propionic acid methyl ester

: 1168134-08-4
2-[4-amino-3-(2,2,2-trifluoroethoxy)phenyl]-3-cyclobutylpropionic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 25 ℃; for 16h; under 2585.81 Torr;

Reference yield:

: 1168134-05-1
2-[4-nitro-3-(2,2,2-trifluoroethoxy)phenyl]acetic acid

: 1168134-08-4
2-[4-amino-3-(2,2,2-trifluoroethoxy)phenyl]-3-cyclobutylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 20 °C

2: potassium hydroxide / dimethyl sulfoxide / 16 h / 40 °C

3: hydrogen; palladium 10% on activated carbon / ethanol / 16 h / 25 °C / 2585.81 Torr

With sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium hydroxide; In ethanol; dimethyl sulfoxide;

Reference yield:

: 1168134-06-2
[4-nitro-3-(2,2,2-trifluoroethoxy)phenyl]acetic acid methyl ester

: 1168134-08-4
2-[4-amino-3-(2,2,2-trifluoroethoxy)phenyl]-3-cyclobutylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / dimethyl sulfoxide / 16 h / 40 °C

2: hydrogen; palladium 10% on activated carbon / ethanol / 16 h / 25 °C / 2585.81 Torr

With palladium 10% on activated carbon; hydrogen; potassium hydroxide; In ethanol; dimethyl sulfoxide;