3,5-Bis-hydroxymethyl-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

Base Information

• Chemical Name: 3,5-Bis-hydroxymethyl-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester
• CAS No.: 193953-33-2
• Molecular Formula: C₃₉H₄₄O₁₂
• Molecular Weight: 704.771
• Mol file: 193953-33-2.mol

Synonyms:3,5-Bis-hydroxymethyl-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

Chemical Property of 3,5-Bis-hydroxymethyl-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-Bis-hydroxymethyl-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

There total 11 articles about 3,5-Bis-hydroxymethyl-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester (193953-30-9) → 3,5-Bis-hydroxymethyl-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester (193953-33-2)

Guidance literature:

With pyridine hydrogenfluoride; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1002/hlca.19970800402

Reference yield:

1,3,5-tris-(methoxycarbonyl)benzene (2672-58-4) → 3,5-Bis-hydroxymethyl-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester (193953-33-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 23 percent / LiAlH₄ / tetrahydrofuran / 0.17 h / 1 - 30 °C

2: KOH / methanol

3: (i-Pr)2NH / dimethylformamide / 24 h / Ambient temperature

4: 81 percent / 1 N KOH / ethanol; H₂O / 0.33 h / Ambient temperature

5: oxalyl chloride / CH₂Cl₂; dimethylformamide / Ambient temperature

6: pyridine / CH₂Cl₂ / 0 °C / to RT

7: 81 percent / HF*pyridine / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; pyridine hydrogenfluoride; diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19970800402

Reference yield:

3,5-bis(hydroxylmethyl)benzoic acid methyl ester (193953-02-5) → 3,5-Bis-hydroxymethyl-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester (193953-33-2)

Guidance literature:

Multi-step reaction with 6 steps

1: KOH / methanol

2: (i-Pr)2NH / dimethylformamide / 24 h / Ambient temperature

3: 81 percent / 1 N KOH / ethanol; H₂O / 0.33 h / Ambient temperature

4: oxalyl chloride / CH₂Cl₂; dimethylformamide / Ambient temperature

5: pyridine / CH₂Cl₂ / 0 °C / to RT

6: 81 percent / HF*pyridine / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; potassium hydroxide; oxalyl dichloride; pyridine hydrogenfluoride; diisopropylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19970800402

upstream raw materials:

3,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester

1,3,5-tris-(methoxycarbonyl)benzene

3,5-bis(hydroxylmethyl)benzoic acid methyl ester

3,5-bis(hydroxylmethyl)benzoic acid