193953-02-5

Basic information

• Product Name: Benzoic acid, 3,5-bis(hydroxymethyl)-, methyl ester
• CAS NO: 193953-02-5
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Mol File: 193953-02-5.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3,5-bis(hydroxymethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3,5-bis(hydroxymethyl)-, methyl ester(193953-02-5)
• EPA Substance Registry System: Benzoic acid, 3,5-bis(hydroxymethyl)-, methyl ester(193953-02-5)

Safety Data

• Hazardous Substances Data: 193953-02-5(Hazardous Substances Data)

Upstream product

• 2672-58-4 1,3,5-tris-(methoxycarbonyl)benzene 
• 18263-95-1 3,5-dicarboxylic acid-1-benzoic acid methyl ester 

Downstream Products

• 1262506-80-8 C₁₆H₂₀O₄ 
• 1262506-81-9 C₁₈H₂₂O₄ 
• 1262506-82-0 3,5-bis[(allyloxy)methyl]benzoic acid 
• 1412914-00-1 3,5-bis[(2-methoxyacetoxy)methyl]benzoic acid 
• 223449-19-2 5-carboxy-m-xylylenebisphosphonic acid tetramethyl ester 
• 223449-25-0 5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester 
• 29333-41-3 methyl 3,5-bis(bromomethyl)benzoate 
• 193953-35-4 (1R)-3-{(1R)-3-[(9H-fluoren-9-yl)methoxy]-1-methyl-3-oxopropoxy}-1-methyl-3-oxopropyl (4R,8R,22R,26R)-31-({[(tert-butyl)diphenylsilyl]oxy}methyl)-4,8,22,26-tetramethyl-2,6,10,20,24,28-hexaoxo-3,7,11,19,23,27-hexaoxatricyclo[27.3.1.1^13.17]tetratriac... 
• 193953-30-9 3,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester 
• 193953-29-6 3,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid (R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethyl ester 
• 193953-07-0 (tert-butyl)diphenylsilyl 3,5-bis[{[(tert-butyl)diphenylsilyl]oxy}methyl]benzoate 
• 193953-33-2 3,5-Bis-hydroxymethyl-benzoic acid (R)-2-((R)-2-{(R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethoxycarbonyl}-1-methyl-ethoxycarbonyl)-1-methyl-ethyl ester 
• 193953-09-2 3,5-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid 

Relevant articles and documents

Study on the structure-activity relationship of dihydroartemisinin derivatives: Discovery, synthesis, and biological evaluation of dihydroartemisinin-bile acid conjugates as potential anticancer agents

A series of dihydroartemisinin derivatives was synthesized, and their anti-proliferation activity against cancer cells was evaluated. Structure-activity relationship studies led to the discovery of dihydroartemisinin-bile acid conjugates that exhibit broa

AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES

The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions comprising the compounds and their use in therapy and diagnostic.

CYTOTOXIC BIS-BENZODIAZEPINE DERIVATIVES AND CONJUGATES THEREOF WITH CELL-BINDING AGENTS FOR INHIBITING ABNORMAL CELL GROWTH OR FOR TREATING PROLIFERATIVE DISEASES

The invention relates to benzodiazepine derivatives with antiproliferative activity and more specifically to benzodiazepine compounds of formulae (I), (II), (TI) and (T2). The invention also provides conjugates of the benzodiazepine compounds linked to a

CYTOTOXIC BENZODIAZEPINE DERIVATIVES

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

PYRAZOLOPYRIDINE DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF

A pyrazolopyridine derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof exhibits a strong EP1 receptor antagonistic effect. Thus, the derivative or the pharmacologically acceptable salt is useful as

Crystal engineering of a microporous, catalytically active fcu topology MOF using a custom-designed metalloporphyrin linker

A 12-connected fcu metal-organic framework (MOF), MMPF-3, has been prepared using a CoII metalloporphyrin. MMPF-3 is comprised of the same polyhedral supermolecular building blocks as the prototypal fcu-MOF, fcu-MOF-1, and its nanoscale cavities feature 18 catalytically active cobalt centers. The high density (ca. 5 cobalt sites/nm3) affords MMPF-3 superior performance in catalytic epoxidation of trans-stilbene compared to other MOFs. Copyright

New water-soluble polyanionic dendrimers - Phosphoric and 1,3,5-benzenetricarboxylic acid derivatives

Simple, very efficient, and having some aspects of generality, synthesis of water-soluble, polyanionic dendrimeric polyesters with different size, polarity, and flexibility is described. These macromolecular compounds consisting of phosphate or thiophosph

Synthesis of new dendrimers - Trimesic acid derivatives

The efficient synthesis of new dendrimeric polyesters up to generation 3 that consist of 1,3,5-benzenetricarboxylic acid building blocks with potential applications in drug delivery is described. The dendrimers possess hydroxy or allyl functional groups o

TRICYCLIC DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. More precisely, the present invention relates to tricyclic derivatives as colchicine derivatives, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. Tricyclic derivatives of the present invention show very powerful cytotoxicity to cancer cell lines but were much less toxic than colchicine or taxol, confirmed through animal toxicity test. Tricyclic derivatives of the invention also decrease the volume and weight of a tumor and have a strong angiogenesis inhibiting activity in HUVEC cells. Thus, tricyclic derivatives of the present invention can effectively be used as an anticancer agent, anti-proliferation agent and an angiogenesis inhibitor.

76. Synthesis of Monodisperse Macromolecular Bicyclic and Dendritic Compounds from (R)-3-Hydroxybutanoic Acid and Benzene-1,3,5-tricarboxylic Acid and Analysis by Fragmenting MALDI-TOF Mass Spectroscopy

As previously shown, oligo- and poly(β-hydroxyalkanoates) have a high tendency to form lamellar crystallites with ca. 50-A thickness which corresponds to chain lengths of 16 units (Fig. 1). To have monodisperse model compounds, we have now prepared bicyclic derivatives with three parallel (27-29) or two parallel and an antiparallel chain (68-70) consisting of up to 16 3-hydroxybutanoate (3-HB) units. We also prepared dendritic compounds (71-75, 82-85) containing oligo(3-HB) chains which cannot possibly he arranged as in the lamellae; the branching units were prepared from trimesic acid (= benzene-1,3,5-tricarboxylic acid). So far, none of the prepared samples formed crystals or contained crystalline domains which would have been suitable for single-crystal or powder-diffraction X-ray analysis. The terminally deprotected dendrimers (74, 75, and 85) are multi-anionic (up to 12 peripheral CO2H groups) and biodegradable. The macromolecular HB derivatives (molecular weight up to 10150 Da) have been fully characterized by IR, 1H- and 13C-NMR, [α]D, and elemental analysis. Especially important is the analysis by mass spectrometry with the MALDI-TOF technique (Fig. 2), proving that the products are monodisperse; application of a new variation of this MS method (post source decay = PSD or fragment analysis by structural time of night = FAST) allows for the observation of metastable fragment ions and, thus, is a tool for structural oligomer analysis (Fig. 3).