Technology Process of 1-(2,3-dideoxy-5-O-(4,4'-dimethoxytrityl)-3-C-hydroxymethyl-β-D-threo-pentofuranosyl)thymine
There total 3 articles about 1-(2,3-dideoxy-5-O-(4,4'-dimethoxytrityl)-3-C-hydroxymethyl-β-D-threo-pentofuranosyl)thymine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 81 percent / pyridinium dichromate, 3A mol. sieve / CH2Cl2 / 2 h / Ambient temperature
2: 79 percent / Zn, TiCl4 / CH2Cl2; tetrahydrofuran / 2 h / Ambient temperature
3: 1.) BH3:1,4-oxathiane, 2.) 2M NaOH, 30percent H2O2 / 1.) THF, room temp., 45 min, 2.) THF, H2O, room temp., 60 min
With
sodium hydroxide; dipyridinium dichromate; borane:1,4-oxathiane; 3 A molecular sieve; dihydrogen peroxide; titanium tetrachloride; zinc;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)81816-0
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 79 percent / Zn, TiCl4 / CH2Cl2; tetrahydrofuran / 2 h / Ambient temperature
2: 1.) BH3:1,4-oxathiane, 2.) 2M NaOH, 30percent H2O2 / 1.) THF, room temp., 45 min, 2.) THF, H2O, room temp., 60 min
With
sodium hydroxide; borane:1,4-oxathiane; dihydrogen peroxide; titanium tetrachloride; zinc;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)81816-0
- Guidance literature:
-
With
sodium hydroxide; borane:1,4-oxathiane; dihydrogen peroxide;
Yield given. Multistep reaction;
1.) THF, room temp., 45 min, 2.) THF, H2O, room temp., 60 min;
DOI:10.1016/S0040-4020(01)81816-0
