1-(2,3-dideoxy-5-O-(4,4'-dimethoxytrityl)-3-C-hydroxymethyl-β-D-threo-pentofuranosyl)thymine

Base Information

Chemical Name:1-(2,3-dideoxy-5-O-(4,4'-dimethoxytrityl)-3-C-hydroxymethyl-β-D-threo-pentofuranosyl)thymine
CAS No.:154371-09-2
Molecular Formula:C₃₂H₃₄N₂O₇
Molecular Weight:558.631
Hs Code.:

Synonyms:1-(2,3-dideoxy-5-O-(4,4'-dimethoxytrityl)-3-C-hydroxymethyl-β-D-threo-pentofuranosyl)thymine

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Chemical Property of 1-(2,3-dideoxy-5-O-(4,4'-dimethoxytrityl)-3-C-hydroxymethyl-β-D-threo-pentofuranosyl)thymine

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Technology Process of 1-(2,3-dideoxy-5-O-(4,4'-dimethoxytrityl)-3-C-hydroxymethyl-β-D-threo-pentofuranosyl)thymine

There total 3 articles about 1-(2,3-dideoxy-5-O-(4,4'-dimethoxytrityl)-3-C-hydroxymethyl-β-D-threo-pentofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 154371-09-2
1-(2,3-dideoxy-5-O-(4,4'-dimethoxytrityl)-3-C-hydroxymethyl-β-D-threo-pentofuranosyl)thymine

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / pyridinium dichromate, 3A mol. sieve / CH₂Cl₂ / 2 h / Ambient temperature

2: 79 percent / Zn, TiCl₄ / CH₂Cl₂; tetrahydrofuran / 2 h / Ambient temperature

3: 1.) BH₃:1,4-oxathiane, 2.) 2M NaOH, 30percent H₂O₂ / 1.) THF, room temp., 45 min, 2.) THF, H₂O, room temp., 60 min

With sodium hydroxide; dipyridinium dichromate; borane:1,4-oxathiane; 3 A molecular sieve; dihydrogen peroxide; titanium tetrachloride; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)81816-0

Reference yield:

: 154371-07-0
5'-O-(4,4'-dimethoxytrityl)-3'-ketothymidine

: 154371-09-2
1-(2,3-dideoxy-5-O-(4,4'-dimethoxytrityl)-3-C-hydroxymethyl-β-D-threo-pentofuranosyl)thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / Zn, TiCl₄ / CH₂Cl₂; tetrahydrofuran / 2 h / Ambient temperature

2: 1.) BH₃:1,4-oxathiane, 2.) 2M NaOH, 30percent H₂O₂ / 1.) THF, room temp., 45 min, 2.) THF, H₂O, room temp., 60 min

With sodium hydroxide; borane:1,4-oxathiane; dihydrogen peroxide; titanium tetrachloride; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)81816-0

Reference yield:

: 154371-08-1
3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-C-methylenethymidine

: 154371-09-2
1-(2,3-dideoxy-5-O-(4,4'-dimethoxytrityl)-3-C-hydroxymethyl-β-D-threo-pentofuranosyl)thymine

Guidance literature:: With sodium hydroxide; borane:1,4-oxathiane; dihydrogen peroxide; Yield given. Multistep reaction; 1.) THF, room temp., 45 min, 2.) THF, H₂O, room temp., 60 min;
DOI:10.1016/S0040-4020(01)81816-0