(2R,5S)-4-benzyloxycarbonylmethyl-5-ethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2R,5S)-4-benzyloxycarbonylmethyl-5-ethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:1403898-85-0
Molecular Formula:C₂₁H₃₂N₂O₄
Molecular Weight:376.496
Hs Code.:

Synonyms:(2R,5S)-4-benzyloxycarbonylmethyl-5-ethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Property of (2R,5S)-4-benzyloxycarbonylmethyl-5-ethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of (2R,5S)-4-benzyloxycarbonylmethyl-5-ethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

There total 6 articles about (2R,5S)-4-benzyloxycarbonylmethyl-5-ethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403898-84-9
(2R,5S)-4-carboxymethyl-5-ethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester triethylamine salt

: 100-39-0
benzyl bromide

: 1403898-85-0
(2R,5S)-4-benzyloxycarbonylmethyl-5-ethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: (2R,5S)-4-carboxymethyl-5-ethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester triethylamine salt; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1403898-80-5
(R)-2-[((S)-2-amino-butyryl)-benzyl-amino]-propionic acid methyl ester hydrochloride

: 1403898-85-0
(2R,5S)-4-benzyloxycarbonylmethyl-5-ethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / ethyl acetate / 18 h / 20 °C

2.1: borane / tetrahydrofuran / 72.25 h / 70 °C / Inert atmosphere

2.2: 2 h / 0 - 70 °C

3.1: potassium carbonate / acetonitrile / 20 °C

4.1: hydrogen; acetic acid / palladium 10% on activated carbon / methanol / 2625.26 Torr

5.1: dichloromethane / 24 h / 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

6.2: 20 °C

With borane; hydrogen; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1403898-82-7
((2S,5R)-4-benzyl-2-ethyl-5-methyl-piperazin-1-yl)-acetic acid benzyl ester

: 1403898-85-0
(2R,5S)-4-benzyloxycarbonylmethyl-5-ethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; acetic acid / palladium 10% on activated carbon / methanol / 2625.26 Torr

2.1: dichloromethane / 24 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 20 °C

With hydrogen; caesium carbonate; acetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;