2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-(5-carbamoyl-1-methyl-1H-pyrrol-3-yl)benzyl acetate

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Chemical Name:2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-(5-carbamoyl-1-methyl-1H-pyrrol-3-yl)benzyl acetate
CAS No.:1413064-50-2
Molecular Formula:C₂₈H₃₂N₄O₄
Molecular Weight:488.586
Hs Code.:

Synonyms:2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-(5-carbamoyl-1-methyl-1H-pyrrol-3-yl)benzyl acetate

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Chemical Property of 2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-(5-carbamoyl-1-methyl-1H-pyrrol-3-yl)benzyl acetate

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Technology Process of 2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-(5-carbamoyl-1-methyl-1H-pyrrol-3-yl)benzyl acetate

There total 5 articles about 2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-(5-carbamoyl-1-methyl-1H-pyrrol-3-yl)benzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1155128-15-6
4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid amide

: 1413064-46-6
2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

: 1413064-50-2
2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-(5-carbamoyl-1-methyl-1H-pyrrol-3-yl)benzyl acetate

Guidance literature:: With potassium phosphate; XPhos; In 1,4-dioxane; water; at 125 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 1413067-31-8
1-(4-bromo-1-methyl-1H-pyrrol-2-yl)-2,2,2-trifluoroethanone

: 1413064-50-2
2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-(5-carbamoyl-1-methyl-1H-pyrrol-3-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / water / 0.75 h / 20 °C

2: potassium phosphate / XPhos / 1,4-dioxane; water / 0.5 h / 125 °C / Microwave irradiation; Inert atmosphere

With ammonium hydroxide; potassium phosphate; XPhos; In 1,4-dioxane; water;

Reference yield:

: 1413067-35-2
6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-3-methyl-3,4-dihydrophthalazin-1(2H)-one

: 1413064-50-2
2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-(5-carbamoyl-1-methyl-1H-pyrrol-3-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 56 h / 20 - 45 °C

2: potassium acetate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / 1,4-dioxane / 18 h / 65 °C / Inert atmosphere; Sealed tube

3: potassium phosphate / XPhos / 1,4-dioxane; water / 0.5 h / 125 °C / Microwave irradiation; Inert atmosphere

With pyridine; potassium phosphate; potassium acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,4-dioxane; dichloromethane; water;