2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-chlorobenzyl acetate

Base Information

Chemical Name:2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-chlorobenzyl acetate
CAS No.:1413064-41-1
Molecular Formula:C₂₂H₂₅ClN₂O₃
Molecular Weight:400.905
Hs Code.:

Synonyms:2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-chlorobenzyl acetate

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Chemical Property of 2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-chlorobenzyl acetate

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Technology Process of 2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-chlorobenzyl acetate

There total 1 articles about 2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-chlorobenzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1413067-35-2
6-tert-butyl-2-(3-chloro-2-(hydroxymethyl)phenyl)-3-methyl-3,4-dihydrophthalazin-1(2H)-one

: 108-24-7
acetic anhydride

: 1413064-41-1
2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-chlorobenzyl acetate

Guidance literature:: With pyridine; In dichloromethane; at 20 - 45 ℃; for 56h;

Reference yield: 82.0%

: 1413064-41-1
2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-chlorobenzyl acetate

: 73183-34-3
bis(pinacol)diborane

: 1413064-46-6
2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

Guidance literature:: With potassium acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,4-dioxane; at 65 ℃; for 18h; Inert atmosphere; Sealed tube;

Reference yield:

: 1413064-41-1
2-(6-tert-butyl-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)-6-chlorobenzyl acetate

: 1413061-18-3
4-[3-(6-tert-Butyl-3-methyl-1-oxo-3,4-dihydro-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / 1,4-dioxane / 18 h / 65 °C / Inert atmosphere; Sealed tube

2: potassium phosphate / XPhos / 1,4-dioxane; water / 0.5 h / 125 °C / Microwave irradiation; Inert atmosphere

3: sodium hydroxide; water / tetrahydrofuran / 4 h / 60 °C

With potassium phosphate; water; potassium acetate; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; water;