4-iodo-(1'-t-butoxycarbonyl-1'-methyl)ethylbenzene

Base Information

• Chemical Name: 4-iodo-(1'-t-butoxycarbonyl-1'-methyl)ethylbenzene
• CAS No.: 228410-37-5
• Molecular Formula: C₁₄H₁₉IO₂
• Molecular Weight: 346.208
• Mol file: 228410-37-5.mol

Synonyms:4-iodo-(1'-t-butoxycarbonyl-1'-methyl)ethylbenzene

Chemical Property of 4-iodo-(1'-t-butoxycarbonyl-1'-methyl)ethylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-iodo-(1'-t-butoxycarbonyl-1'-methyl)ethylbenzene

There total 3 articles about 4-iodo-(1'-t-butoxycarbonyl-1'-methyl)ethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

potassium tert-butylate (865-47-4) + 4-iodo-(1'-carboxy-1'-methyl)ethylbenzene (228410-36-4) → 4-iodo-(1'-t-butoxycarbonyl-1'-methyl)ethylbenzene (228410-37-5)

Guidance literature:

4-iodo-(1'-carboxy-1'-methyl)ethylbenzene; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 1h;

potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.333333h;

Reference yield: 81.0%

potassium tert-butylate (865-47-4) + 2-(4-iodo-phenyl)-2-methyl-propionyl chloride → 4-iodo-(1'-t-butoxycarbonyl-1'-methyl)ethylbenzene (228410-37-5)

Guidance literature:

In tetrahydrofuran;

DOI:10.1021/jm000446q

Reference yield:

4-iodo-(1'-carboxy-1'-methyl)ethylbenzene (228410-36-4) → 4-iodo-(1'-t-butoxycarbonyl-1'-methyl)ethylbenzene (228410-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂; dimethylformamide / 1 h

2: 81 percent / tetrahydrofuran

With oxalyl dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm000446q

upstream raw materials:

potassium tert-butylate

4-iodo-(1'-carboxy-1'-methyl)ethylbenzene

Downstream raw materials:

3-[2'-(R,S)-(dimethyl)-naphthylacetylamino-3'-[4''-(1'''-carboxy-1'''-methyl)ethyl]benzene]propanoylamino-1-(4-methoxybenzyl)-4-methyl-2-pyridone

2-{4-[(S)-2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-2-(2-methyl-2-naphthalen-2-yl-propionylamino)-ethyl]-phenyl}-2-methyl-propionic acid

2-{4-[(R)-2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-2-(2-methyl-2-naphthalen-2-yl-propionylamino)-ethyl]-phenyl}-2-methyl-propionic acid

3-[2'-(R,S)-t-butoxycarbonylamino-3'-[4''-(1'''-t-butoxycarbonyl-1'''-methyl)ethyl]benzene]propanoylamino-1-(4-methoxybenzyl)-4-methyl-2-pyridone

Refernces

• 1、 Proudfoot,Betageri,Cardozo,Gilmore,Glynn,Hickey,Jakes,Kabcenell,Kirrane,Tibolla,Lukas,Patel,Sharma,Yazdanian,Moss,Beaulieu,Cameron,Ferland,Gauthier,Gillard,Gorys,Poirier,Rancourt,Wernic,Montse. "Nonpeptidic, monocharged, cell permeable ligands for the p56lck SH2 domain". . p. 2421 - 2431. Retrieved 2007/10/03.