2-[4-[2(S)-[N-[1-(4-Methoxybenzyl)-4-methyl-2-oxo-1,2-dihydropyridin-3-yl]carbamoyl]-2-[2-methyl-2-(2-naphthyl)propionamido]ethyl]phenyl]-2-methylpropionic acid

Base Information

Chemical Name:2-[4-[2(S)-[N-[1-(4-Methoxybenzyl)-4-methyl-2-oxo-1,2-dihydropyridin-3-yl]carbamoyl]-2-[2-methyl-2-(2-naphthyl)propionamido]ethyl]phenyl]-2-methylpropionic acid
CAS No.:228408-75-1
Molecular Formula:C₄₁H₄₃N₃O₆
Molecular Weight:673.809
Hs Code.:

2-[4-[2(S)-[N-[1-(4-Methoxybenzyl)-4-methyl-2-oxo-1,2-dihydropyridin-3-yl]carbamoyl]-2-[2-methyl-2-(2-naphthyl)propionamido]ethyl]phenyl]-2-methylpropionic acid

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Chemical Property of 2-[4-[2(S)-[N-[1-(4-Methoxybenzyl)-4-methyl-2-oxo-1,2-dihydropyridin-3-yl]carbamoyl]-2-[2-methyl-2-(2-naphthyl)propionamido]ethyl]phenyl]-2-methylpropionic acid

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Technology Process of 2-[4-[2(S)-[N-[1-(4-Methoxybenzyl)-4-methyl-2-oxo-1,2-dihydropyridin-3-yl]carbamoyl]-2-[2-methyl-2-(2-naphthyl)propionamido]ethyl]phenyl]-2-methylpropionic acid

There total 42 articles about 2-[4-[2(S)-[N-[1-(4-Methoxybenzyl)-4-methyl-2-oxo-1,2-dihydropyridin-3-yl]carbamoyl]-2-[2-methyl-2-(2-naphthyl)propionamido]ethyl]phenyl]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21901-18-8
4-Methyl-3-nitro-2-pyridone

: 228408-75-1
2-{4-[(R)-2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-2-(2-methyl-2-naphthalen-2-yl-propionylamino)-ethyl]-phenyl}-2-methyl-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 1 h

1.2: 56 percent / dimethylformamide / 20 °C

2.1: 96 percent / H₂ / 10percent Pd/C / ethanol / 5.5 h / 2068.65 Torr

3.1: EDC / CH₂Cl₂ / 0.17 h / 0 °C

3.2: 67 percent / CH₂Cl₂ / 52 h / 20 °C

4.1: 4M HCl / dioxane / 0.75 h / 0 - 20 °C

5.1: EDC / CH₂Cl₂ / 1 h / 20 °C

6.1: TFA / 2 h

6.2: chiral HPLC

With hydrogenchloride; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; 10percent Pd/C; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000446q

Reference yield:

: 21901-18-8
4-Methyl-3-nitro-2-pyridone

: 228408-75-1
2-{4-[(S)-2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-2-(2-methyl-2-naphthalen-2-yl-propionylamino)-ethyl]-phenyl}-2-methyl-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 1 h

1.2: 56 percent / dimethylformamide / 20 °C

2.1: 96 percent / H₂ / 10percent Pd/C / ethanol / 5.5 h / 2068.65 Torr

3.1: EDC / CH₂Cl₂ / 0.17 h / 0 °C

3.2: 67 percent / CH₂Cl₂ / 52 h / 20 °C

4.1: 4M HCl / dioxane / 0.75 h / 0 - 20 °C

5.1: EDC / CH₂Cl₂ / 1 h / 20 °C

6.1: TFA / 2 h

6.2: chiral HPLC

With hydrogenchloride; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; 10percent Pd/C; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000446q

Reference yield:

: 21901-18-8
4-Methyl-3-nitro-2-pyridone

: 228408-75-1
3-[2'-(R,S)-(dimethyl)-naphthylacetylamino-3'-[4''-(1'''-carboxy-1'''-methyl)ethyl]benzene]propanoylamino-1-(4-methoxybenzyl)-4-methyl-2-pyridone

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 1 h

1.2: 56 percent / dimethylformamide / 20 °C

2.1: 96 percent / H₂ / 10percent Pd/C / ethanol / 5.5 h / 2068.65 Torr

3.1: EDC / CH₂Cl₂ / 0.17 h / 0 °C

3.2: 67 percent / CH₂Cl₂ / 52 h / 20 °C

4.1: 4M HCl / dioxane / 0.75 h / 0 - 20 °C

5.1: EDC / CH₂Cl₂ / 1 h / 20 °C

6.1: TFA / 2 h

With hydrogenchloride; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; 10percent Pd/C; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000446q