2-[4-[2(S)-[N-[1-(4-Methoxybenzyl)-4-methyl-2-oxo-1,2-dihydropyridin-3-yl]carbamoyl]-2-[2-methyl-2-(2-naphthyl)propionamido]ethyl]phenyl]-2-methylpropionic acid

Base Information

• Chemical Name: 2-[4-[2(S)-[N-[1-(4-Methoxybenzyl)-4-methyl-2-oxo-1,2-dihydropyridin-3-yl]carbamoyl]-2-[2-methyl-2-(2-naphthyl)propionamido]ethyl]phenyl]-2-methylpropionic acid
• CAS No.: 228408-75-1
• Molecular Formula: C₄₁H₄₃N₃O₆
• Molecular Weight: 673.809
• Mol file: 228408-75-1.mol

Synonyms:

Chemical Property of 2-[4-[2(S)-[N-[1-(4-Methoxybenzyl)-4-methyl-2-oxo-1,2-dihydropyridin-3-yl]carbamoyl]-2-[2-methyl-2-(2-naphthyl)propionamido]ethyl]phenyl]-2-methylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-[2(S)-[N-[1-(4-Methoxybenzyl)-4-methyl-2-oxo-1,2-dihydropyridin-3-yl]carbamoyl]-2-[2-methyl-2-(2-naphthyl)propionamido]ethyl]phenyl]-2-methylpropionic acid

There total 42 articles about 2-[4-[2(S)-[N-[1-(4-Methoxybenzyl)-4-methyl-2-oxo-1,2-dihydropyridin-3-yl]carbamoyl]-2-[2-methyl-2-(2-naphthyl)propionamido]ethyl]phenyl]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Methyl-3-nitro-2-pyridone (21901-18-8) → 2-{4-[(R)-2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-2-(2-methyl-2-naphthalen-2-yl-propionylamino)-ethyl]-phenyl}-2-methyl-propionic acid (228408-75-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 1 h

1.2: 56 percent / dimethylformamide / 20 °C

2.1: 96 percent / H₂ / 10percent Pd/C / ethanol / 5.5 h / 2068.65 Torr

3.1: EDC / CH₂Cl₂ / 0.17 h / 0 °C

3.2: 67 percent / CH₂Cl₂ / 52 h / 20 °C

4.1: 4M HCl / dioxane / 0.75 h / 0 - 20 °C

5.1: EDC / CH₂Cl₂ / 1 h / 20 °C

6.1: TFA / 2 h

6.2: chiral HPLC

With hydrogenchloride; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; 10percent Pd/C; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm000446q

Reference yield:

4-Methyl-3-nitro-2-pyridone (21901-18-8) → 2-{4-[(S)-2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-2-(2-methyl-2-naphthalen-2-yl-propionylamino)-ethyl]-phenyl}-2-methyl-propionic acid (228408-75-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 1 h

1.2: 56 percent / dimethylformamide / 20 °C

2.1: 96 percent / H₂ / 10percent Pd/C / ethanol / 5.5 h / 2068.65 Torr

3.1: EDC / CH₂Cl₂ / 0.17 h / 0 °C

3.2: 67 percent / CH₂Cl₂ / 52 h / 20 °C

4.1: 4M HCl / dioxane / 0.75 h / 0 - 20 °C

5.1: EDC / CH₂Cl₂ / 1 h / 20 °C

6.1: TFA / 2 h

6.2: chiral HPLC

With hydrogenchloride; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; 10percent Pd/C; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm000446q

Reference yield:

4-Methyl-3-nitro-2-pyridone (21901-18-8) → 3-[2'-(R,S)-(dimethyl)-naphthylacetylamino-3'-[4''-(1'''-carboxy-1'''-methyl)ethyl]benzene]propanoylamino-1-(4-methoxybenzyl)-4-methyl-2-pyridone (228408-75-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 1 h

1.2: 56 percent / dimethylformamide / 20 °C

2.1: 96 percent / H₂ / 10percent Pd/C / ethanol / 5.5 h / 2068.65 Torr

3.1: EDC / CH₂Cl₂ / 0.17 h / 0 °C

3.2: 67 percent / CH₂Cl₂ / 52 h / 20 °C

4.1: 4M HCl / dioxane / 0.75 h / 0 - 20 °C

5.1: EDC / CH₂Cl₂ / 1 h / 20 °C

6.1: TFA / 2 h

With hydrogenchloride; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; 10percent Pd/C; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm000446q

upstream raw materials:

4-Methyl-3-nitro-2-pyridone

2-methyl-2-(naphth-2-yl)propanoic acid

p-methoxybenzyl chloride

4-iodo-(1'-carboxy-1'-methyl)ethylbenzene