4-FLUOROPHENYLGLYCINE-N-BOC PROTECTED

Base Information

• Chemical Name: 4-FLUOROPHENYLGLYCINE-N-BOC PROTECTED
• CAS No.: 142121-93-5
• Molecular Formula: C13H16 F N O4
• Molecular Weight: 269.273
• Hs Code.: 2924190090
• Mol file: 142121-93-5.mol

Synonyms:Benzeneaceticacid, a-[[(1,1-dimethylethoxy)carbonyl]amino]-4-fluoro-, (?à)-;(tert-butoxycarbonylamino)(4-fluorophenyl)acetic acid;2-[(tert-Butoxycarbonyl)amino]-2-(4-fluorophenyl)acetic acid;[(tert-Butoxycarbonyl)amino](4-fluorophenyl)acetic acid

Chemical Property of 4-FLUOROPHENYLGLYCINE-N-BOC PROTECTED

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 41-43 °C
• Boiling Point: 408.417oC at 760 mmHg
• PKA: 3.47±0.10(Predicted)
• Flash Point: 200.804oC
• PSA: 79.12000
• Density: 1.243g/cm3
• LogP: 2.68050

Purity/Quality:

97% ^*data from raw suppliers

a-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-4-Fluoro-BenzeneAcetic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUOROPHENYLGLYCINE-N-BOC PROTECTED

There total 7 articles about 4-FLUOROPHENYLGLYCINE-N-BOC PROTECTED which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + (2RS)-N-(p-fluorophenyl)glycine (7292-73-1) → 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetic acid (142121-93-5)

Guidance literature:

With sodium hydroxide; In water; isopropyl alcohol; at 20 ℃; for 1h; Cooling with ice;

Reference yield: 70.0%

carbon dioxide (124-38-9,18923-20-1) + [Benzenesulfonyl-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester → 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetic acid (142121-93-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; at 0 ℃; under 760.051 Torr; Electrochemical reaction;

DOI:10.1021/acs.joc.1c01516

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + [Benzenesulfonyl-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester → 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetic acid (142121-93-5) + (4-fluorobenzyl)carbamic acid tert-butyl ester (153903-23-2)

Guidance literature:

[Benzenesulfonyl-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester; With trimethylsilyltributyltin; cesium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

carbon dioxide; In N,N-dimethyl-formamide; at 100 ℃; for 3h; under 7500.75 Torr; Autoclave;

With hydrogenchloride; In diethyl ether; water; N,N-dimethyl-formamide; pH=2; Inert atmosphere;

DOI:10.1002/anie.201006422

upstream raw materials:

tert-butyl carbazate

carbon dioxide

4-fluorobenzaldehyde

di-tert-butyl dicarbonate