tert-butyl (2S,3S,5S)-3,5-dihydroxy-1,6-diphenylhexan-2-ylcarbamate

Base Information

• Chemical Name: tert-butyl (2S,3S,5S)-3,5-dihydroxy-1,6-diphenylhexan-2-ylcarbamate
• CAS No.: 1040741-01-2
• Molecular Formula: C₂₃H₃₁NO₄
• Molecular Weight: 385.503
• Mol file: 1040741-01-2.mol

Synonyms:tert-butyl (2S,3S,5S)-3,5-dihydroxy-1,6-diphenylhexan-2-ylcarbamate

Chemical Property of tert-butyl (2S,3S,5S)-3,5-dihydroxy-1,6-diphenylhexan-2-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (2S,3S,5S)-3,5-dihydroxy-1,6-diphenylhexan-2-ylcarbamate

There total 1 articles about tert-butyl (2S,3S,5S)-3,5-dihydroxy-1,6-diphenylhexan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (2S,3S)-3-hydroxy-5-oxo-1,6-diphenylhexan-2-ylcarbamate (1040740-90-6) → tert-butyl (2S,3S,5S)-3,5-dihydroxy-1,6-diphenylhexan-2-ylcarbamate (1040741-01-2)

Guidance literature:

tert-butyl (2S,3S)-3-hydroxy-5-oxo-1,6-diphenylhexan-2-ylcarbamate; With air; tributyl borane; In tetrahydrofuran; at 20 ℃; for 2h;

With lithium borohydride; In tetrahydrofuran; at -78 ℃; for 4h;

With dihydrogen peroxide; In tetrahydrofuran; methanol; phosphate buffer; at 20 ℃; for 18h; Further stages.;

DOI:10.1016/j.tet.2008.04.049

Reference yield: 97.0%

tert-butyl (2S,3S,5S)-3,5-dihydroxy-1,6-diphenylhexan-2-ylcarbamate (1040741-01-2) + 2,2-dimethoxy-propane (77-76-9) → tert-butyl (S)-1-((4S,6S)-6-benzyl-2,2-dimethyl-1,3-dioxan-4-yl)-2-phenylethylcarbamate (1040741-16-9)

Guidance literature:

With camphor-10-sulfonic acid; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2008.04.049

upstream raw materials:

tert-butyl (2S,3S)-3-hydroxy-5-oxo-1,6-diphenylhexan-2-ylcarbamate

Downstream raw materials:

tert-butyl (S)-1-((4S,6S)-6-benzyl-2,2-dimethyl-1,3-dioxan-4-yl)-2-phenylethylcarbamate