[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(3-trimethylsilyloxyanhlino)methyl]benzoate

Base Information

Chemical Name:[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(3-trimethylsilyloxyanhlino)methyl]benzoate
CAS No.:1612897-07-0
Molecular Formula:C₃₂H₃₄Cl₂N₂O₆Si
Molecular Weight:641.623
Hs Code.:

Synonyms:[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(3-trimethylsilyloxyanhlino)methyl]benzoate

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Chemical Property of [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(3-trimethylsilyloxyanhlino)methyl]benzoate

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Technology Process of [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(3-trimethylsilyloxyanhlino)methyl]benzoate

There total 9 articles about [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(3-trimethylsilyloxyanhlino)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36309-43-0
3-((trimethylsilyl)oxy)aniline

: 1611454-85-3
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-formylbenzoate

: 1612897-07-0
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(3-trimethylsilyloxyanhlino)methyl]benzoate

: 1612897-09-2
C₂₉H₂₆Cl₂N₂O₆

Guidance literature:: 3-((trimethylsilyl)oxy)aniline; [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-formylbenzoate; In dichloromethane; at 20 ℃; for 20h;

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 4h; Overall yield = 100 %; Overall yield = 457 mg;

Reference yield:

: 591-27-5
m-Hydroxyaniline

: 1612897-07-0
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(3-trimethylsilyloxyanhlino)methyl]benzoate

: 1612897-09-2
C₂₉H₂₆Cl₂N₂O₆

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 18 h / Reflux

2.1: dichloromethane / 20 h / 20 °C

2.2: 4 h / 20 °C

With sulfuric acid; In dichloromethane;

Reference yield:

: 100868-46-0
3,5-dichloro-4-picoline

: 1612897-07-0
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(3-trimethylsilyloxyanhlino)methyl]benzoate

: 1612897-09-2
C₂₉H₂₆Cl₂N₂O₆

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: methanol; chloroform / 2 h / 20 °C / Resolution of racemate

4.1: potassium tert-butylate / methanol / 24 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 5 h / 20 °C

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 21 h / 20 °C

7.1: dichloromethane / 20 h / 20 °C

7.2: 4 h / 20 °C

With dmap; potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;