5-(3,4-dimethoxyphenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole

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Chemical Name:5-(3,4-dimethoxyphenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole
CAS No.:1448594-04-4
Molecular Formula:C₂₅H₂₂N₄O₄
Molecular Weight:442.474
Hs Code.:

Synonyms:5-(3,4-dimethoxyphenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole

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Chemical Property of 5-(3,4-dimethoxyphenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole

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Technology Process of 5-(3,4-dimethoxyphenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole

There total 3 articles about 5-(3,4-dimethoxyphenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1448772-66-4
(Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide

: 93-07-2
Veratric acid

: 1448594-04-4
5-(3,4-dimethoxyphenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole

Guidance literature:: Veratric acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

(Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide; In dichloromethane; at 0 - 110 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.06.042

Reference yield:

: 16435-03-3
4-((2-phenylhydrazono)methyl)phenol

: 1448594-04-4
5-(3,4-dimethoxyphenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloroamine-T / ethanol / 3 h / Reflux

2.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 110 °C / Inert atmosphere

With hydroxylamine hydrochloride; chloroamine-T; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2013.06.042

Reference yield:

: 1448593-90-5
3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carbonitrile

: 1448594-04-4
5-(3,4-dimethoxyphenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 110 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2013.06.042