(Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide

Base Information

Chemical Name:(Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide
CAS No.:1448772-66-4
Molecular Formula:C₁₆H₁₆N₄O₂
Molecular Weight:296.329
Hs Code.:

Synonyms:(Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide

Suppliers and Price of (Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide

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Technology Process of (Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide

There total 2 articles about (Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1448593-90-5
3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carbonitrile

: 1448772-66-4
(Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide

Guidance literature:: With hydroxylamine hydrochloride; sodium carbonate; In ethanol; water; Reflux;
DOI:10.1016/j.bmcl.2013.06.042

Reference yield:

: 16435-03-3
4-((2-phenylhydrazono)methyl)phenol

: 1448772-66-4
(Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide

Guidance literature:: Multi-step reaction with 2 steps

1: chloroamine-T / ethanol / 3 h / Reflux

2: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / Reflux

With hydroxylamine hydrochloride; chloroamine-T; sodium carbonate; In ethanol; water;
DOI:10.1016/j.bmcl.2013.06.042

Reference yield: 73.0%

: 1448772-66-4
(Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide

: 74-11-3
para-chlorobenzoic acid

: 1448594-03-3
5-(4-chlorophenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole

Guidance literature:: para-chlorobenzoic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

(Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide; In dichloromethane; at 0 - 110 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.06.042