3-(5-ethyl-4-oxo-2,3,4,5-tetrahydro-1H-cyclopenta[c]quinolin-8-yl)-4-trifluoromethoxybenzaldehyde

Base Information

Chemical Name:3-(5-ethyl-4-oxo-2,3,4,5-tetrahydro-1H-cyclopenta[c]quinolin-8-yl)-4-trifluoromethoxybenzaldehyde
CAS No.:932400-79-8
Molecular Formula:C₂₂H₁₈F₃NO₃
Molecular Weight:401.385
Hs Code.:

Synonyms:3-(5-ethyl-4-oxo-2,3,4,5-tetrahydro-1H-cyclopenta[c]quinolin-8-yl)-4-trifluoromethoxybenzaldehyde

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Chemical Property of 3-(5-ethyl-4-oxo-2,3,4,5-tetrahydro-1H-cyclopenta[c]quinolin-8-yl)-4-trifluoromethoxybenzaldehyde

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Technology Process of 3-(5-ethyl-4-oxo-2,3,4,5-tetrahydro-1H-cyclopenta[c]quinolin-8-yl)-4-trifluoromethoxybenzaldehyde

There total 4 articles about 3-(5-ethyl-4-oxo-2,3,4,5-tetrahydro-1H-cyclopenta[c]quinolin-8-yl)-4-trifluoromethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 932400-78-7
8-bromo-5-ethyl-1,2,3,5-tetrahydrocyclopenta[c]quinolin-4-one

: 459810-97-0
3-formyl-6-trifluoromethoxy-1-phenyl boronic acid

: 932400-79-8
3-(5-ethyl-4-oxo-2,3,4,5-tetrahydro-1H-cyclopenta[c]quinolin-8-yl)-4-trifluoromethoxybenzaldehyde

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 80 ℃; for 4h;

Reference yield:

: 95515-78-9
8-bromo-1,2,3,5-tetrahydro-4H-cyclopenta[c]quinolin-4-one

: 932400-79-8
3-(5-ethyl-4-oxo-2,3,4,5-tetrahydro-1H-cyclopenta[c]quinolin-8-yl)-4-trifluoromethoxybenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / dimethylsulfoxide / 12 h / 20 °C

2: aq. K₂CO₃ / Pd(PPh₃)4 / toluene; ethanol / Heating

With potassium hydroxide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dimethyl sulfoxide; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.01.047

Reference yield:

: 91844-16-5
2-oxo-cyclopentanecarboxylic acid-(4-bromo-anilide)

: 932400-79-8
3-(5-ethyl-4-oxo-2,3,4,5-tetrahydro-1H-cyclopenta[c]quinolin-8-yl)-4-trifluoromethoxybenzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: KOH / dimethylsulfoxide / 12 h / 20 °C

2: aq. K₂CO₃ / Pd(PPh₃)4 / toluene; ethanol / Heating

With potassium hydroxide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dimethyl sulfoxide; toluene; 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.01.047