91844-16-5Relevant academic research and scientific papers
A Chiral Phenanthroline Ligand with a Hydrogen-Bonding Site: Application to the Enantioselective Amination of Methylene Groups
Annapureddy, Rajasekar Reddy,Jandl, Christian,Bach, Thorsten
, p. 7374 - 7378 (2020)
A silver-catalyzed amination is reported that occurs at the aliphatic C3-substituent of various quinolones and pyridones. The C-H amination reaction proceeded with high site-and enantioselectivity (14 examples, 83-97% ee). The key to its success is the use of a chiral phenanthroline ligand that is attached via an ethynyl linker to the 8-position of octahydro-1H-4,7-methanoisoindol-1-one. AgPF6 (10 mol %) served as the silver source, PhI.NNs as the nitrene precursor, and 1,10-phenanthroline as the coligand. The reaction outcome can be understood by assuming a nitrene C-H insertion within a hydrogen-bonded silver complex in which a single C-H bond is exposed to the catalytic reaction center.
Usual and unusual reactions of cyclohexane-1,2-dione with aryl azides and amines: a structural corrigendum
Singh, Neeraj,Banert, Klaus
supporting information, p. 1897 - 1901 (2017/03/09)
The reported syntheses of alleged functionalised 1,2,3-triazines from cyclohexane-1,2-dione and aryl azides, in the presence of pyrrolidine and other amines, were repeated. The products do not contain the bicyclic triazine and bicyclic ketone moieties; instead, cyclohexane-fused 4,5-dihydro-1,2,3-triazoles and monocyclic β-ketoamides were obtained, respectively. These corrections are well supported by careful analyses of NMR spectra, IR spectra, elemental analysis and comparison with data which were previously published in the literature. Suitable mechanisms are discussed for the synthesis of the observed compounds.
RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia
Lagu, Bharat,Pio, Barbara,Lebedev, Rimma,Yang, Maria,Pelton, Patricia D.
, p. 3497 - 3503 (2008/02/09)
A number of RXR agonists were synthesized and screened in functional assays. The synthesis and the structure-activity relationship (SAR) within the series of compounds will be presented. Some in vivo data in rodent models for dyslipidemia and diabetes wil
