2-<(4-bromo-2-fluorophenyl)methyl>-6-fluoro-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

Base Information

• Chemical Name: 2-<(4-bromo-2-fluorophenyl)methyl>-6-fluoro-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid
• CAS No.: 129688-85-3
• Molecular Formula: C₂₀H₁₄BrF₂NO₆
• Molecular Weight: 482.235

Synonyms:2-<(4-bromo-2-fluorophenyl)methyl>-6-fluoro-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

Chemical Property of 2-<(4-bromo-2-fluorophenyl)methyl>-6-fluoro-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

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Technology Process of 2-<(4-bromo-2-fluorophenyl)methyl>-6-fluoro-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid

There total 1 articles about 2-<(4-bromo-2-fluorophenyl)methyl>-6-fluoro-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-<(4-bromo-2-fluorophenyl)methyl>-6-fluoro-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid (129688-85-3)

Guidance literature:

Reference yield: 95.0%

N-(methoxycarbonyl)-N'-tert-butylcarbodiimide + 2-<(4-bromo-2-fluorophenyl)methyl>-6-fluoro-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid (129688-85-3) → <<2-<(4-bromo-2-fluorophenyl)methyl>-6-fluoro-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolinyl>acetyl>carbamic acid methyl ester

Guidance literature:

In tetrahydrofuran; for 12h; Heating;

DOI:10.1021/jm00039a018

Reference yield: 71.0%

2-<(4-bromo-2-fluorophenyl)methyl>-6-fluoro-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid (129688-85-3) → 2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid (133891-93-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; water; for 0.5h;

DOI:10.1021/jm00039a018

Downstream raw materials:

2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

1'-Amino-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone

2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester

2-(4-Bromo-2-fluoro-benzyl)-6-fluoro-4-methylcarbamoylmethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid methyl ester

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