methyl 4-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-2-iodobenzoate

Base Information

• Chemical Name: methyl 4-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-2-iodobenzoate
• CAS No.: 1610434-46-2
• Molecular Formula: C₂₅H₂₇IO₃Si
• Molecular Weight: 530.478
• Mol file: 1610434-46-2.mol

Synonyms:methyl 4-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-2-iodobenzoate

Chemical Property of methyl 4-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-2-iodobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-2-iodobenzoate

There total 2 articles about methyl 4-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-2-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tert-butylchlorodiphenylsilane (58479-61-1) + methyl 4-(hydroxymethyl)-2-iodobenzoate (191104-99-1) → methyl 4-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-2-iodobenzoate (1610434-46-2)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

DOI:10.3390/molecules25133058

Reference yield:

[3-iodo-4-(methoxycarbonyl)]benzoic acid (299173-24-3) → methyl 4-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-2-iodobenzoate (1610434-46-2)

Guidance literature:

Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: pyridine / 12 h / 20 °C

With pyridine; borane-THF; In tetrahydrofuran;

DOI:10.1002/ejoc.201301792 DOI:10.1002/ejoc.201301792

Reference yield: 97.0%

methyl 4-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-2-iodobenzoate (1610434-46-2) + (5-isopropyl-2-methoxyphenyl)boronic acid (216393-63-4) → methyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-5'-isopropyl-2'-methoxy-[1,1'-biphenyl]-2-carboxylate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at -78 - 100 ℃; Microwave irradiation; High pressure;

DOI:10.3390/molecules26133944

upstream raw materials:

tert-butylchlorodiphenylsilane

methyl 4-(hydroxymethyl)-2-iodobenzoate

[3-iodo-4-(methoxycarbonyl)]benzoic acid

Downstream raw materials:

methyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2’,5’-dimethoxy-[1,1’-biphenyl]-2-carboxylate

2-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-2’,5’-dimethoxy-[1,1’-biphenyl]-2-yl)propan-2-ol