phenyl 4-(hydroxymethyl)piperidine-1-carboxylate

Base Information

• Chemical Name: phenyl 4-(hydroxymethyl)piperidine-1-carboxylate
• CAS No.: 1183687-01-5
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 235.283
• Mol file: 1183687-01-5.mol

Synonyms:phenyl 4-(hydroxymethyl)piperidine-1-carboxylate

Chemical Property of phenyl 4-(hydroxymethyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl 4-(hydroxymethyl)piperidine-1-carboxylate

There total 2 articles about phenyl 4-(hydroxymethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-piperidinemethanol (6457-49-4) + phenyl chloroformate (1885-14-9) → phenyl 4-(hydroxymethyl)piperidine-1-carboxylate (1183687-01-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1039/c6md00683c

Reference yield:

ethyl 1-phenoxycarbonyl-4-piperidinecarboxylic acid (1156196-73-4) → phenyl 4-(hydroxymethyl)piperidine-1-carboxylate (1183687-01-5)

Guidance literature:

ethyl 1-phenoxycarbonyl-4-piperidinecarboxylic acid; With sodium tetrahydroborate; calcium chloride; In tetrahydrofuran; at 10 ℃;

With ethanol; In water; at 20 ℃; Cooling with ice;

Reference yield: 23.0%

phenyl 4-(hydroxymethyl)piperidine-1-carboxylate (1183687-01-5) → phenyl 4-(bromomethyl)piperidine-1-carboxylate

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 96h;

DOI:10.1039/c6md00683c

upstream raw materials:

ethyl 1-phenoxycarbonyl-4-piperidinecarboxylic acid

4-piperidinemethanol

phenyl chloroformate