5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-methylthio-1H-pyrazole-3-carbonitrile

Base Information

• Chemical Name: 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-methylthio-1H-pyrazole-3-carbonitrile
• CAS No.: 120068-55-5
• Molecular Formula: C₁₂H₇Cl₂F₃N₄S
• Molecular Weight: 367.182

Synonyms:5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-methylthio-1H-pyrazole-3-carbonitrile

Chemical Property of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-methylthio-1H-pyrazole-3-carbonitrile

Chemical Property:

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Technology Process of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-methylthio-1H-pyrazole-3-carbonitrile

There total 4 articles about 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-methylthio-1H-pyrazole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl bromide (74-83-9) + 4,4'-dithiobis [5-amino-3-cyano-1-{2,6-dichloro-4-(trifluoromethyl)phenyl}-1H-pyrazole] (130755-46-3) → 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-methylthio-1H-pyrazole-3-carbonitrile (120068-55-5)

Guidance literature:

With disodium hydrogenphosphate; sodium dithionite; In water; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1016/j.jfluchem.2006.04.002

Reference yield: 92.0%

4,4'-dithiobis [5-amino-3-cyano-1-{2,6-dichloro-4-(trifluoromethyl)phenyl}-1H-pyrazole] (130755-46-3) + methyl iodide (74-88-4) → 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-methylthio-1H-pyrazole-3-carbonitrile (120068-55-5)

Guidance literature:

With dipotassium hydrogenphosphate; sodium dithionite; In water; N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1021/jf1001793

Reference yield:

5-amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-4-thiocyanato-1H-pyrazole-3-carbonitrile (120069-10-5) → 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-methylthio-1H-pyrazole-3-carbonitrile (120068-55-5)

Guidance literature:

With potassium hydroxide; carbon dioxide; In methanol; water;

upstream raw materials:

methyl bromide

4,4'-dithiobis [5-amino-3-cyano-1-{2,6-dichloro-4-(trifluoromethyl)phenyl}-1H-pyrazole]

5-amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-4-thiocyanato-1H-pyrazole-3-carbonitrile

2,6-dichloro-4-(trifluoromethyl)aniline

Downstream raw materials:

1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-dimethylamino-4-methylthio-1H-pyrazole-3-carbonitrile

C₁₅H₁₀Cl₅F₃N₄O₂S

C₁₆H₁₂Cl₅F₃N₄O₂S

C₁₇H₁₄Cl₅F₃N₄O₂S

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