5-[4-(1,1-dioxothiomorpholin-4-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Base Information

• Chemical Name: 5-[4-(1,1-dioxothiomorpholin-4-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
• CAS No.: 1257705-09-1
• Molecular Formula: C₁₇H₁₉N₅O₂S
• Molecular Weight: 357.436
• Mol file: 1257705-09-1.mol

Synonyms:5-[4-(1,1-dioxothiomorpholin-4-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Chemical Property of 5-[4-(1,1-dioxothiomorpholin-4-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Chemical Property:

• Density: 1.48±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

[1,2,4]Triazolo[1,5-a]pyridin-2-amine,5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]phenyl]- 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[4-(1,1-dioxothiomorpholin-4-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

There total 15 articles about 5-[4-(1,1-dioxothiomorpholin-4-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

C20H24N4O4S2 → 5-[4-(1,1-dioxothiomorpholin-4-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (1257705-09-1)

Guidance literature:

With hydroxylamine hydrochloride; aniline; In tert-butyl alcohol; at 50 ℃; for 24h; Temperature; Reagent/catalyst; Solvent; Green chemistry;

Reference yield: 79.0%

4-[(4-boronophenyl)methyl]thiomorpholine 1,1-dioxide (747413-23-6) + 5-Bromo-[1,2,4]Triazolo[1,5-a]pyridine-2-ylamine (1010120-55-4) → 5-[4-(1,1-dioxothiomorpholin-4-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (1257705-09-1)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; at 80 ℃; for 18h; Product distribution / selectivity; Inert atmosphere; Sealed tube;

Reference yield: 54.0%

4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-thiomorpholine-1,1-dioxide (1092563-25-1) + 5-Bromo-[1,2,4]Triazolo[1,5-a]pyridine-2-ylamine (1010120-55-4) → 5-[4-(1,1-dioxothiomorpholin-4-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (1257705-09-1)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 16h; Inert atmosphere;

upstream raw materials:

4-[(4-boronophenyl)methyl]thiomorpholine 1,1-dioxide

5-Bromo-[1,2,4]Triazolo[1,5-a]pyridine-2-ylamine

4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-thiomorpholine-1,1-dioxide

N-(5-{4-[(1,1-dioxo-1λ⁶-thiomorpholin-4-yl)methyl]phenyl}-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide

Downstream raw materials:

N-(5-{4-[(1,1-dioxo-1λ⁶-thiomorpholin-4-yl)methyl]phenyl}-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide