C₂₉H₃₇NO₃Si

Base Information

• Chemical Name: C₂₉H₃₇NO₃Si
• CAS No.: 1346132-35-1
• Molecular Formula: C₂₉H₃₇NO₃Si
• Molecular Weight: 475.703
• Mol file: 1346132-35-1.mol

Synonyms:C₂₉H₃₇NO₃Si

Chemical Property of C₂₉H₃₇NO₃Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C₂₉H₃₇NO₃Si

There total 3 articles about C₂₉H₃₇NO₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyl chloroformate (501-53-1,94274-21-2) + (5-azido-pentyloxy)-tert-butyl-diphenyl-silane (288580-32-5) → C29H37NO3Si (1346132-35-1)

Guidance literature:

(5-azido-pentyloxy)-tert-butyl-diphenyl-silane; With water; triphenylphosphine; In tetrahydrofuran; at 40 ℃; for 10h; Inert atmosphere;

benzyl chloroformate; With triethylamine; In tetrahydrofuran; Inert atmosphere;

DOI:10.1002/adsc.201100282

Reference yield:

5-(tert-butyldiphenylsilyloxy)pentan-1-ol (121671-76-9) → C29H37NO3Si (1346132-35-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.1: sodium azide / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

3.1: water; triphenylphosphine / tetrahydrofuran / 10 h / 40 °C / Inert atmosphere

3.2: Inert atmosphere

With sodium azide; water; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/adsc.201100282

Reference yield:

5-(tert-butyldiphenylsilyloxy)pentyl methanesulfonate (928657-95-8) → C29H37NO3Si (1346132-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium azide / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

2.1: water; triphenylphosphine / tetrahydrofuran / 10 h / 40 °C / Inert atmosphere

2.2: Inert atmosphere

With sodium azide; water; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/adsc.201100282

upstream raw materials:

5-(tert-butyldiphenylsilyloxy)pentan-1-ol

benzyl chloroformate

(5-azido-pentyloxy)-tert-butyl-diphenyl-silane

5-(tert-butyldiphenylsilyloxy)pentyl methanesulfonate

Downstream raw materials:

(R)-N-benzyloxycarbonyl-2-(4-methyl-2-oxopentyl)piperidine

(R)-N-benzyloxycarbonyl-2-(2-oxo-2-phenylethyl)piperidine

(R)-N-benzyloxycarbonyl-2-(2-oxo-2-p-tolylethyl)piperidine

(R)-N-benzyloxycarbonyl-2-(2-(4-nitrophenyl)-2-oxoethyl)piperidine