(3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Base Information

• Chemical Name: (3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide
• CAS No.: 856449-27-9
• Molecular Formula: C₂₁H₂₅N₃O₃
• Molecular Weight: 367.448
• Mol file: 856449-27-9.mol

Synonyms:(3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Chemical Property of (3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

There total 4 articles about (3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

8-hydroxy-2,3-dimethyl-7-(3-oxo-3-phenylpropyl)imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (498529-53-6) → (3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (856449-27-9)

Guidance literature:

8-hydroxy-2,3-dimethyl-7-(3-oxo-3-phenylpropyl)imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide; With potassium tert-butylate; hydrogen; (S)-Xyl-PPhosRuCl₂(S)-DAIPEN; In water; isopropyl alcohol; tert-butyl alcohol; at 65 ℃; for 22h; under 60006 Torr;

With hydrogenchloride; ammonium chloride; In dichloromethane; water; isopropyl alcohol; tert-butyl alcohol; at 20 ℃; Product distribution / selectivity;

Reference yield: 50.0%

8-hydroxy-2,3-dimethyl-7-((E)-3-phenylallyl)imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide → (3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (856449-27-9)

Guidance literature:

8-hydroxy-2,3-dimethyl-7-((E)-3-phenylallyl)imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide; With (+)-alpine boramine TMEDA complex; boron trifluoride diethyl etherate; In tetrahydrofuran; at 20 ℃; for 5h;

With potassium hydroxide; dihydrogen peroxide; In tetrahydrofuran; ethanol; water; for 0.5h;

With ammonium chloride; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

C28H31N3O3 → (3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (856449-27-9)

Guidance literature:

With cyclohexa-1,4-diene; palladium on activated charcoal; In ethanol; at 80 ℃; for 2h;

DOI:10.1016/j.tetasy.2007.10.013

upstream raw materials:

8-hydroxy-2,3-dimethyl-7-(3-oxo-3-phenylpropyl)imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Downstream raw materials:

C₄₁H₃₉F₆N₃O₇

(3R)-8-(tert-butyl-dimethylsilanyloxy)-7-(3-hydroxy-3-phenyl-propyl)-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

(9S)-2,3-dimethyl-9-phenyl-7H-8,9-dihydropyrano[2,3-c]imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide