(3R)-8-(tert-butyl-dimethylsilanyloxy)-7-(3-hydroxy-3-phenyl-propyl)-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Base Information

• Chemical Name: (3R)-8-(tert-butyl-dimethylsilanyloxy)-7-(3-hydroxy-3-phenyl-propyl)-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide
• CAS No.: 856698-68-5
• Molecular Formula: C₂₇H₃₉N₃O₃Si
• Molecular Weight: 481.71
• Mol file: 856698-68-5.mol

Synonyms:(3R)-8-(tert-butyl-dimethylsilanyloxy)-7-(3-hydroxy-3-phenyl-propyl)-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Chemical Property of (3R)-8-(tert-butyl-dimethylsilanyloxy)-7-(3-hydroxy-3-phenyl-propyl)-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-8-(tert-butyl-dimethylsilanyloxy)-7-(3-hydroxy-3-phenyl-propyl)-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

There total 1 articles about (3R)-8-(tert-butyl-dimethylsilanyloxy)-7-(3-hydroxy-3-phenyl-propyl)-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (856449-27-9) + 8-hydroxy-7-((S)-3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (856698-65-2) + tert-butyldimethylsilyl chloride (18162-48-6) → (3S)-8-(tert-butyl-dimethylsilanyloxy)-7-(3-hydroxy-3-phenyl-propyl)-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide + (3R)-8-(tert-butyl-dimethylsilanyloxy)-7-(3-hydroxy-3-phenyl-propyl)-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (856698-68-5)

Guidance literature:

(3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide; 8-hydroxy-7-((S)-3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide; tert-butyldimethylsilyl chloride; With triethylamine; In dichloromethane; for 5.25h; Heating / reflux;

With ammonium chloride; In dichloromethane; water;

Reference yield:

(3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (856449-27-9) + 8-hydroxy-7-((S)-3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (856698-65-2) + (3S)-8-(tert-butyl-dimethylsilanyloxy)-7-(3-hydroxy-3-phenyl-propyl)-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide + (3R)-8-(tert-butyl-dimethylsilanyloxy)-7-(3-hydroxy-3-phenyl-propyl)-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide (856698-68-5) + (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → C41H39F6N3O7 (1000293-68-4) + C41H39F6N3O7

Guidance literature:

With pyridine; In tetrachloromethane; dichloromethane; at 20 ℃; for 6h;

upstream raw materials:

(3R)-8-hydroxy-7-(3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

8-hydroxy-7-((S)-3-hydroxy-3-phenylpropyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid dimethylamide

tert-butyldimethylsilyl chloride

Downstream raw materials:

C₄₁H₃₉F₆N₃O₇