BOC-D-MEPHE(4-CL)-OH

Base Information

• Chemical Name: BOC-D-MEPHE(4-CL)-OH
• CAS No.: 125324-00-7
• Molecular Formula: C15H20 Cl N O4
• Molecular Weight: 313.781
• Hs Code.: 2924299090
• Mol file: 125324-00-7.mol

Synonyms:N-(tert-Butoxycarbonyl)-N-methyl-D-4-chlorophenylalanine

Chemical Property of BOC-D-MEPHE(4-CL)-OH

Chemical Property:

• PSA: 66.84000
• LogP: 3.20260

Purity/Quality:

98%min ^*data from raw suppliers

Boc-N-methyl-4-chloro-D-phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-D-MEPHE(4-CL)-OH

There total 1 articles about BOC-D-MEPHE(4-CL)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Boc-D-(4-Cl)Phe-OH (57292-44-1) + methyl iodide (74-88-4) → (R)-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-chlorophenyl)propanoic acid (125324-00-7,179033-68-2)

Guidance literature:

N-Boc-D-(4-Cl)Phe-OH; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.666667h;

methyl iodide; In tetrahydrofuran; at 0 ℃; for 16.3333h;

Reference yield: 85.0%

(R)-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-chlorophenyl)propanoic acid (125324-00-7,179033-68-2) + N-Me-Gly-L-Ile-OTce HCl salt → Boc-N-Me-4-Cl-D-Phe-N-Me-Gly-L-Ile-OTce

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 14h;

DOI:10.1016/j.tet.2013.01.089

Reference yield: 72.0%

(R)-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-chlorophenyl)propanoic acid (125324-00-7,179033-68-2) + 4-piperidone hydrochloride (41979-39-9) → C20H27ClN2O4 (1198179-30-4)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2009.08.024

upstream raw materials:

N-Boc-D-(4-Cl)Phe-OH

methyl iodide

Downstream raw materials:

(R)-3-(4-chlorophenyl)-2-methylaminopropionic acid

C₂₀H₂₇ClN₂O₄

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