(5S)-5-hydroxymethyl-3-(p-methoxyphenyl)-4,5-dihydroisoxazole

Base Information

• Chemical Name: (5S)-5-hydroxymethyl-3-(p-methoxyphenyl)-4,5-dihydroisoxazole
• CAS No.: 721430-38-2
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol file: 721430-38-2.mol

Synonyms:(5S)-5-hydroxymethyl-3-(p-methoxyphenyl)-4,5-dihydroisoxazole

Chemical Property of (5S)-5-hydroxymethyl-3-(p-methoxyphenyl)-4,5-dihydroisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5S)-5-hydroxymethyl-3-(p-methoxyphenyl)-4,5-dihydroisoxazole

There total 7 articles about (5S)-5-hydroxymethyl-3-(p-methoxyphenyl)-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-{3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl}methyl acetate → (5S)-5-hydroxymethyl-3-(p-methoxyphenyl)-4,5-dihydroisoxazole (721430-38-2)

Guidance literature:

With immobilized lipase B from Candida antarctica; In aq. phosphate buffer; toluene; at 25 ℃; for 12h; pH=7;

DOI:10.1016/j.ejmech.2016.07.026

Reference yield:

[(5RS)-3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl]methanol (206055-84-7) → (5S)-5-hydroxymethyl-3-(p-methoxyphenyl)-4,5-dihydroisoxazole (721430-38-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap / dichloromethane / 20 °C

2: immobilized lipase B from Candida antarctica / aq. phosphate buffer; toluene / 0.12 h / 25 °C / pH 7

3: immobilized lipase B from Candida antarctica / aq. phosphate buffer; toluene / 12 h / 25 °C / pH 7

With dmap; In aq. phosphate buffer; dichloromethane; toluene;

DOI:10.1016/j.ejmech.2016.07.026

Reference yield:

{3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl}methyl acetate → (5S)-5-hydroxymethyl-3-(p-methoxyphenyl)-4,5-dihydroisoxazole (721430-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: immobilized lipase B from Candida antarctica / aq. phosphate buffer; toluene / 0.12 h / 25 °C / pH 7

2: immobilized lipase B from Candida antarctica / aq. phosphate buffer; toluene / 12 h / 25 °C / pH 7

With immobilized lipase B from Candida antarctica; In aq. phosphate buffer; toluene;

DOI:10.1016/j.ejmech.2016.07.026

upstream raw materials:

allyl alcohol

N-hydroxy-4-methoxy-benzenecarboximidoyl chloride

p-methoxyl benzaldoxime

(5S)-5-[(1-benzyl-5,5-dimethyl-3-oxo-2-pyrazolidinyl)carbonyl]-3-(p-methoxyphenyl)-4,5-dihydroisoxazole

Downstream raw materials:

(S)-3-(4-Methoxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid