(1R,2R)-2-[(6-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]-N-(1-cyanocyclopropyl)cyclohexanecarboxamide

Base Information

Chemical Name:(1R,2R)-2-[(6-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]-N-(1-cyanocyclopropyl)cyclohexanecarboxamide
CAS No.:1095263-33-4
Molecular Formula:C₂₃H₂₅BrN₄O₂
Molecular Weight:469.381
Hs Code.:

Synonyms:(1R,2R)-2-[(6-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]-N-(1-cyanocyclopropyl)cyclohexanecarboxamide

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Chemical Property of (1R,2R)-2-[(6-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]-N-(1-cyanocyclopropyl)cyclohexanecarboxamide

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Technology Process of (1R,2R)-2-[(6-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]-N-(1-cyanocyclopropyl)cyclohexanecarboxamide

There total 5 articles about (1R,2R)-2-[(6-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]-N-(1-cyanocyclopropyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: C₁₉H₂₁BrN₂O₃

: 127946-77-4
1-amino-1-cyclopropanecarbonitrile hydrochloride

: 1095263-33-4
(1R,2R)-2-[(6-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]-N-(1-cyanocyclopropyl)cyclohexanecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm3007257

Reference yield: 65.0%

: 1095263-33-4
(1R,2R)-2-[(6-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]-N-(1-cyanocyclopropyl)cyclohexanecarboxamide

Guidance literature:

Reference yield:

: 46022-05-3
(1R,2R)-(-)-trans-cyclohexane-1,2-dicarboxylic acid

: 1095263-33-4
(1R,2R)-2-[(6-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]-N-(1-cyanocyclopropyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic anhydride / 1 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 20 °C

With acetic anhydride; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm3007257