tri-tert-butyl N-{4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-methylamino]benzoyl}-L-γ-glutamyl-D-glutamate

Base Information

Chemical Name:tri-tert-butyl N-{4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-methylamino]benzoyl}-L-γ-glutamyl-D-glutamate
CAS No.:902777-40-6
Molecular Formula:C₄₈H₆₇N₅O₁₁
Molecular Weight:890.087
Hs Code.:

tri-tert-butyl N-{4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-methylamino]benzoyl}-L-γ-glutamyl-D-glutamate

Synonyms:tri-tert-butyl N-{4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-methylamino]benzoyl}-L-γ-glutamyl-D-glutamate

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Chemical Property of tri-tert-butyl N-{4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-methylamino]benzoyl}-L-γ-glutamyl-D-glutamate

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Technology Process of tri-tert-butyl N-{4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-methylamino]benzoyl}-L-γ-glutamyl-D-glutamate

There total 5 articles about tri-tert-butyl N-{4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-methylamino]benzoyl}-L-γ-glutamyl-D-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-methylamino]benzoic acid trifluoroacetic acid salt 2:1

: 145817-20-5
L-γ-glutamyl-D-glutamic acid tris(1,1-dimethylethyl)ester

: 902777-40-6
tri-tert-butyl N-{4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-methylamino]benzoyl}-L-γ-glutamyl-D-glutamate

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;
DOI:10.1016/j.bmc.2006.03.001

Reference yield:

: 157701-46-7
tert-butyl 4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)amino]benzoate

: 902777-40-6
tri-tert-butyl N-{4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-methylamino]benzoyl}-L-γ-glutamyl-D-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: AcOH / tetrahydrofuran; H₂O / 6 h / 20 °C

1.2: 97 percent / sodium cyanoborohydride / tetrahydrofuran; H₂O / 20 h / 20 °C

2.1: 0.16 g / 2 h / 20 °C

3.1: 79 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 2.5 h / 20 °C

With diethyl cyanophosphonate; acetic acid; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.03.001

Reference yield:

: 902777-34-8
tert-butyl 4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-methylamino]benzoate

: 902777-40-6
tri-tert-butyl N-{4-[N-(2-methyl-3-(2,2-dimethylpropionyloxymethyl)-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-methylamino]benzoyl}-L-γ-glutamyl-D-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 0.16 g / 2 h / 20 °C

2: 79 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 2.5 h / 20 °C

With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.03.001