3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid hydrochloride salt

Base Information

Chemical Name:3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid hydrochloride salt
CAS No.:1035155-13-5
Molecular Formula:C₂₃H₂₉F₂NO₃*ClH
Molecular Weight:441.946
Hs Code.:

Synonyms:3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid hydrochloride salt

Suppliers and Price of 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid hydrochloride salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid hydrochloride salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid hydrochloride salt

There total 19 articles about 3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1035154-04-1
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid

: 1035155-13-5
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid hydrochloride salt

Guidance literature:: With hydrogenchloride; In diethyl ether; acetonitrile;

Reference yield:

: 5-bromo-2,3-difluoro-phenol

: 1035155-13-5
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid hydrochloride salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: propiononitrile / 0.25 h / 120 °C

1.2: 22 h / 20 °C

2.1: hydrogen / 5% palladium over charcoal / ethanol / 42.5 h / 2844.39 Torr

2.2: 0.5 h / 3102.97 Torr

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: lithium chloride / bis(tributylphosphine) palladium / N,N-dimethyl-formamide / 22 h / 20 °C

4.2: 2 h / 20 °C

5.1: AD-mix-α / water; tert-butyl alcohol / 0 - 20 °C

5.2: 5 h / 20 °C

6.1: pyridine / 4.62 h / -20 - -10 °C

7.1: potassium carbonate / ethanol / 96 h / 20 °C

8.1: ethanol / 36 h / 70 °C

9.1: sodium hydroxide; water / methanol / 15 h / 20 °C

10.1: hydrogenchloride / diethyl ether; acetonitrile

With pyridine; hydrogenchloride; sodium hydroxide; AD-mix-α; water; hydrogen; potassium carbonate; triethylamine; lithium chloride; bis(tributylphosphine) palladium; 5% palladium over charcoal; In methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; propiononitrile; tert-butyl alcohol; 4.1: Curtius Rearrangement;

Reference yield:

: 1035154-98-3
ethyl 3-(3,4-difluoro-5-hydroxyphenyl)propanoate

: 1035155-13-5
3-(3-{(1S)-2-[(1,1-dimethyl-4-phenylbutyl)amino]-1-hydroxyethyl}-4,5-difluorophenyl)propanoic acid hydrochloride salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: lithium chloride / bis(tributylphosphine) palladium / N,N-dimethyl-formamide / 22 h / 20 °C

2.2: 2 h / 20 °C

3.1: AD-mix-α / water; tert-butyl alcohol / 0 - 20 °C

3.2: 5 h / 20 °C

4.1: pyridine / 4.62 h / -20 - -10 °C

5.1: potassium carbonate / ethanol / 96 h / 20 °C

6.1: ethanol / 36 h / 70 °C

7.1: sodium hydroxide; water / methanol / 15 h / 20 °C

8.1: hydrogenchloride / diethyl ether; acetonitrile

With pyridine; hydrogenchloride; sodium hydroxide; AD-mix-α; water; potassium carbonate; triethylamine; lithium chloride; bis(tributylphosphine) palladium; In methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 2.1: Curtius Rearrangement;