(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-ethylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Base Information

Chemical Name:(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-ethylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide
CAS No.:1401624-47-2
Molecular Formula:C₂₆H₃₃N₅O₃S
Molecular Weight:495.646
Hs Code.:

Synonyms:(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-ethylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

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Chemical Property of (S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-ethylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

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Technology Process of (S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-ethylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

There total 11 articles about (S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-ethylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: tert-butyl (S)-1-((1R,2R)-1-cyano-2-(4-(4-ethylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate

: 1401624-47-2
(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-ethylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Guidance literature:: tert-butyl (S)-1-((1R,2R)-1-cyano-2-(4-(4-ethylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate; With formic acid; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 1161813-60-0
(1R,2R)-methyl 1-amino-2-(4-bromophenyl)cyclopropanecarboxylate

: 1401624-47-2
(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-ethylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

1.2: 20 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 4

3.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C

3.2: 20 °C

4.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 20 °C / Inert atmosphere; Reflux

6.1: formic acid / 4 h / 20 °C

With 4-methyl-morpholine; formic acid; 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1401625-45-3
C₁₉H₂₅BrN₂O₅

: 1401624-47-2
(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-ethylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C

1.2: 20 °C

2.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 20 °C / Inert atmosphere; Reflux

4.1: formic acid / 4 h / 20 °C

With formic acid; 1,3,5-trichloro-2,4,6-triazine; chloroformic acid ethyl ester; sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;