H-D-ARG(MTR)-OH

Base Information

• Chemical Name: H-D-ARG(MTR)-OH
• CAS No.: 200114-52-9
• Molecular Formula: C₁₆H₂₆N₄O₅S
• Molecular Weight: 386.472
• Mol file: 200114-52-9.mol

Synonyms:

Chemical Property of H-D-ARG(MTR)-OH

Chemical Property:

• PSA: 162.98000
• LogP: 3.27780
• Storage Temp.: Store at RT.

Purity/Quality:

98% ^*data from raw suppliers

H-D-Arg(Mtr)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-D-ARG(MTR)-OH

There total 6 articles about H-D-ARG(MTR)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (80745-07-9) → L-Arg(Mtr) (80745-10-4,200114-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 4 N NaOH / 1.) acetone, 3 h, 2.) ethyl acetate

2: 1.) 0.2 N H₂SO₄, 2.) hydrogen / 2.) palladium black / 1.) ethyl acetate, 2.) methanol

With sodium hydroxide; sulfuric acid; hydrogen; palladium;

Reference yield:

2,3,5-trimethylanisole (20469-61-8) → L-Arg(Mtr) (80745-10-4,200114-52-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 72.5 percent / chlorosulfonic acid / CH₂Cl₂ / -10 - -5 °C

2: 1.) 4 N NaOH / 1.) acetone, 3 h, 2.) ethyl acetate

3: 1.) 0.2 N H₂SO₄, 2.) hydrogen / 2.) palladium black / 1.) ethyl acetate, 2.) methanol

With chlorosulfonic acid; sodium hydroxide; sulfuric acid; hydrogen; palladium; In dichloromethane;

Reference yield:

2,3,5-trimethylphenol (697-82-5) → L-Arg(Mtr) (80745-10-4,200114-52-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 99.8 percent / 60percent NaH in oil / dimethylsulfoxide / 10 h / Ambient temperature

2: 72.5 percent / chlorosulfonic acid / CH₂Cl₂ / -10 - -5 °C

3: 1.) 4 N NaOH / 1.) acetone, 3 h, 2.) ethyl acetate

4: 1.) 0.2 N H₂SO₄, 2.) hydrogen / 2.) palladium black / 1.) ethyl acetate, 2.) methanol

With chlorosulfonic acid; sodium hydroxide; sulfuric acid; hydrogen; sodium hydride; palladium; In dichloromethane; dimethyl sulfoxide;

upstream raw materials:

Z-Arg(Mtr)-OH

Z-Arg(Mtr)-OH*CHA

2,3,5-trimethylanisole

2,3,5-trimethylphenol

Downstream raw materials:

kyotorphin acetate salt

Boc-Tyr(Bzl)-Arg(Mtr)-OH

Refernces

• 1、 -. "Method for protecting guanidino group and restoring the same". . . Retrieved 2008/06/13.