4-(1-benzenesulfonyl-1H-indol-3-yl)-2-(diethoxyphosphoryl)-4-oxobutyric acid

Base Information

Chemical Name:4-(1-benzenesulfonyl-1H-indol-3-yl)-2-(diethoxyphosphoryl)-4-oxobutyric acid
CAS No.:916818-29-6
Molecular Formula:C₂₄H₂₈NO₈PS
Molecular Weight:521.528
Hs Code.:

Synonyms:4-(1-benzenesulfonyl-1H-indol-3-yl)-2-(diethoxyphosphoryl)-4-oxobutyric acid

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Chemical Property of 4-(1-benzenesulfonyl-1H-indol-3-yl)-2-(diethoxyphosphoryl)-4-oxobutyric acid

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Technology Process of 4-(1-benzenesulfonyl-1H-indol-3-yl)-2-(diethoxyphosphoryl)-4-oxobutyric acid

There total 2 articles about 4-(1-benzenesulfonyl-1H-indol-3-yl)-2-(diethoxyphosphoryl)-4-oxobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 916818-21-8
3-(1-benzenesulfonyl-1H-indol-3-yl)-2,2-dibromoethanone

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 916818-29-6
4-(1-benzenesulfonyl-1H-indol-3-yl)-2-(diethoxyphosphoryl)-4-oxobutyric acid

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran;

3-(1-benzenesulfonyl-1H-indol-3-yl)-2,2-dibromoethanone; With sodium iodide; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1016/j.tet.2006.09.003

Reference yield:

: 99532-45-3
3-acetyl-1-benzenesulfonylindole

: 916818-29-6
4-(1-benzenesulfonyl-1H-indol-3-yl)-2-(diethoxyphosphoryl)-4-oxobutyric acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 10 percent / pyridinium hydrobromide perbromide / CHCl₃ / 0.5 h / Heating

2.1: NaH / tetrahydrofuran

2.2: 72 percent / NaI / tetrahydrofuran / 1.5 h / 20 °C

With pyridinium hydrobromide perbromide; sodium hydride; In tetrahydrofuran; chloroform;
DOI:10.1016/j.tet.2006.09.003

Reference yield: 23.0%

: 916818-29-6
4-(1-benzenesulfonyl-1H-indol-3-yl)-2-(diethoxyphosphoryl)-4-oxobutyric acid

: 58885-60-2
N-(tert-butoxycarbonyl)-3-aminopropanal

: 2-[2-(1-benzenesulfonyl-1H-indol-3-yl)-2-oxo-ethyl]-5-tert-butoxycarbonylamino-pent-2-enoic acid ethyl ester

Guidance literature:: 4-(1-benzenesulfonyl-1H-indol-3-yl)-2-(diethoxyphosphoryl)-4-oxobutyric acid; With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃;

N-(tert-butoxycarbonyl)-3-aminopropanal; In tetrahydrofuran; at -78 - 20 ℃; for 18h;
DOI:10.1016/j.tet.2006.09.003