99532-45-3

Basic information

• Product Name: 3-ACETYL-1-(PHENYLSULFONYL)INDOLE
• Synonyms: 3-ACETYL-1-(PHENYLSULFONYL)INDOLE
• CAS NO: 99532-45-3
• Molecular Formula: C₁₆H₁₃NO₃S
• Molecular Weight: 299.34432
• Mol File: 99532-45-3.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-ACETYL-1-(PHENYLSULFONYL)INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ACETYL-1-(PHENYLSULFONYL)INDOLE(99532-45-3)
• EPA Substance Registry System: 3-ACETYL-1-(PHENYLSULFONYL)INDOLE(99532-45-3)

Safety Data

• Hazardous Substances Data: 99532-45-3(Hazardous Substances Data)

Upstream product

• 703-80-0 3-acetylindole 
• 98-59-9 p-toluenesulfonyl chloride 
• 98-09-9 benzenesulfonyl chloride 
• 40899-71-6 1-benzenesulfonylindole 
• 75-36-5 acetyl chloride 
• 20356-45-0 3-(1H-indol-3-yl)-3-oxo-propionitrile 
• 120-72-9 indole 
• 117760-49-3 3-(1-methylethenyl)-1-phenylsulfonyl-1H-indole 
• 108-24-7 acetic anhydride 
• 99655-68-2 3-bromo-1-phenylsulfonyl indole 

Downstream Products

• 153524-94-8 (Z)-1-(Phenylsulfonyl)-3-(α-methyl-β-methoxyvinyl)indole 
• 153524-93-7 (E)-1-(Phenylsulfonyl)-3-(α-methyl-β-methoxyvinyl)indole 
• 703-80-0 3-acetylindole 
• 19012-02-3 N-methyl-3-acetylindole 
• 1226854-00-7 1-[1-(3-methylbutyl)-1H-indol-3-yl]ethanone 
• 1226853-99-1 C₁₄H₁₇NO 
• 1226854-01-8 1-(1-pentyl-1H-indol-3-yl)ethanone 
• 915917-10-1 1-(1-(2-methoxyethyl)-1H-indol-3-yl)ethan-1-one 
• 949035-36-3 1-(1-isopropyl-1H-indol-3-yl)ethan-1-one 
• 93315-38-9 3-acetyl-1-benzyl-1H-indole 
• 1356239-56-9 C₂₄H₂₁N₃O₃S 

Relevant articles and documents

Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities

A series of Pyrazolo[1,5-a]Pyrimidine analogs were designed and synthesized as novel tubulin inhibitors. Among them, compounds 1a and 1b showed the highest antiproliferative activity against a panel of cancer cell lines with average IC50 values

Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety

Thirty-six N-arylsulfonyl-3-substituted indoles were designed and synthesized by combining the N-arylsulfonylindoles with aminoguanidine, semicarbazide, and thiosemicarbazide, respectively. Their antibacterial activities were screened, and cytotoxic activities were evaluated. The results showed that aminoguanidines (6) exhibited much better antibacterial activity than semicarbazides (7) and thiosemicarbazides (8). Most compounds in series 6 showed potent inhibitory activity against the tested bacterial strains, including multidrug-resistant strains, with MIC values in the range of 1.08–23.46 μM. The cytotoxic activity of the compounds 6c, 6d, 6h, 6j, 6k and 6l was assessed in two human cancer cell lines A590 and SGC7901, and one human normal cell line HEK 293T. The results indicated that compounds selected exhibited excellent activity against the tested cancer cells with IC50 values in the range of 1.51–15.12 μM suggesting the potential of them as new antibacterial and anticancer agents. What's more, the results of resistance study revealed that resistance of the tested bacteria toward 6d is not easily developed. Molecular docking studies revealed that the aminoguanidine and arylsulfonylindole moieties played a significant role in binding the target site of E. coli FabH-CoA receptor.

Indole compound and applications thereof, and pharmaceutical composition and applications thereof

The present invention provides an indole compound and applications thereof, wherein the compound can effectively inhibit a CBP/EP300 Bromodomain receptor, and can be used as a drug for cancers, inflammatory diseases, autoimmune diseases, septicemia and viral infections.