3-(1H-benzo[d]imidazol-2-yl)-5-(tert-butyl)-2-hydroxybenzaldehyde

Base Information

• Chemical Name: 3-(1H-benzo[d]imidazol-2-yl)-5-(tert-butyl)-2-hydroxybenzaldehyde
• CAS No.: 1356156-67-6
• Molecular Formula: C₁₈H₁₈N₂O₂
• Molecular Weight: 294.353
• Mol file: 1356156-67-6.mol

Synonyms:3-(1H-benzo[d]imidazol-2-yl)-5-(tert-butyl)-2-hydroxybenzaldehyde

Chemical Property of 3-(1H-benzo[d]imidazol-2-yl)-5-(tert-butyl)-2-hydroxybenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1H-benzo[d]imidazol-2-yl)-5-(tert-butyl)-2-hydroxybenzaldehyde

There total 4 articles about 3-(1H-benzo[d]imidazol-2-yl)-5-(tert-butyl)-2-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(E)-3-(((2-aminophenyl)imino)methyl)-5-(tert-butyl)-2-hydroxybenzaldehyde → 3-(1H-benzo[d]imidazol-2-yl)-5-(tert-butyl)-2-hydroxybenzaldehyde (1356156-67-6)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1039/c3ra41456f

Reference yield:

2-hydroxy-5-t-butylisophthalaldehyde (84501-28-0) → 3-(1H-benzo[d]imidazol-2-yl)-5-(tert-butyl)-2-hydroxybenzaldehyde (1356156-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 6 h / 50 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 20 °C

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In ethanol; dichloromethane;

DOI:10.1039/c3ra41456f

Reference yield:

para-tert-butylphenol (98-54-4) → 3-(1H-benzo[d]imidazol-2-yl)-5-(tert-butyl)-2-hydroxybenzaldehyde (1356156-67-6)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / 24 h / Inert atmosphere; Reflux

2: ethanol / 6 h / 50 °C

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 20 °C

With trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In ethanol; dichloromethane;

DOI:10.1039/c3ra41456f

upstream raw materials:

2-hydroxy-5-t-butylisophthalaldehyde

para-tert-butylphenol

1,2-diamino-benzene