2-sec-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Base Information

Chemical Name:2-sec-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one
CAS No.:89848-59-9
Molecular Formula:C₃₆H₄₀Cl₂N₈O₄
Molecular Weight:719.671
Hs Code.:

2-sec-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Synonyms:2-sec-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

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Chemical Property of 2-sec-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

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Technology Process of 2-sec-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

There total 10 articles about 2-sec-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 78-76-2,5787-31-5
s-butyl bromide

: 89848-42-0
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

: 89848-59-9
2-sec-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide;
DOI:10.1021/jm00373a015

Reference yield:

: 100-00-5
4-chlorobenzonitrile

: 89848-59-9
2-sec-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

2: 80 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

3: 86 percent / pyridine / CHCl₃ / 3 h

4: 99 percent / hydrazine hydrate / dioxane / 3 h / Heating

5: 38 percent / NaOAc / butan-1-ol

6: 68 percent / KOH / dimethylsulfoxide

With thiophene; pyridine; potassium hydroxide; hydrogen; sodium acetate; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm00373a015

Reference yield:

: 67914-86-7,854372-78-4
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-59-9
2-sec-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) Me₂SO, 1 h, 2.) Me₂SO, 80 deg C, 5 h

2: 70 percent / NaOH / butan-1-ol / Heating

3: 50 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

4: 80 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

5: 86 percent / pyridine / CHCl₃ / 3 h

6: 99 percent / hydrazine hydrate / dioxane / 3 h / Heating

7: 38 percent / NaOAc / butan-1-ol

8: 68 percent / KOH / dimethylsulfoxide

With thiophene; pyridine; potassium hydroxide; sodium hydroxide; hydrogen; sodium acetate; sodium hydride; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm00373a015