1-(3-bromo-4-(methoxymethoxy)phenyl)-7-(3-hydroxy-4-methoxyphenyl)heptan-3-one

Base Information

Chemical Name:1-(3-bromo-4-(methoxymethoxy)phenyl)-7-(3-hydroxy-4-methoxyphenyl)heptan-3-one
CAS No.:1354834-22-2
Molecular Formula:C₂₂H₂₇BrO₅
Molecular Weight:451.357
Hs Code.:

Synonyms:1-(3-bromo-4-(methoxymethoxy)phenyl)-7-(3-hydroxy-4-methoxyphenyl)heptan-3-one

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Chemical Property of 1-(3-bromo-4-(methoxymethoxy)phenyl)-7-(3-hydroxy-4-methoxyphenyl)heptan-3-one

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Technology Process of 1-(3-bromo-4-(methoxymethoxy)phenyl)-7-(3-hydroxy-4-methoxyphenyl)heptan-3-one

There total 13 articles about 1-(3-bromo-4-(methoxymethoxy)phenyl)-7-(3-hydroxy-4-methoxyphenyl)heptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1354834-33-5
(E)-1-(3-bromo-4-(methoxymethoxy)phenyl)-7-(3-hydroxy-4-methoxyphenyl)hept-6-en-3-one

: 1354834-22-2
1-(3-bromo-4-(methoxymethoxy)phenyl)-7-(3-hydroxy-4-methoxyphenyl)heptan-3-one

Guidance literature:: With palladium on activated charcoal; hydrogen; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.bmcl.2011.11.025

Reference yield: 78.0%

: 1-(3-bromo-4-(methoxymethoxy)phenyl)-7-(3-hydroxy-4-methoxyphenyl)hept-1-en-3-one

: 1354834-22-2
1-(3-bromo-4-(methoxymethoxy)phenyl)-7-(3-hydroxy-4-methoxyphenyl)heptan-3-one

Guidance literature:: With diphenyl sulfide; palladium 10% on activated carbon; hydrogen; In chloroform; at 20 ℃; for 7h; under 375.038 Torr;
DOI:10.1016/j.tetlet.2012.05.142

Reference yield:

: 5597-50-2
3-(4-hydroxyphenyl)propionic acid methyl ester

: 1354834-22-2
1-(3-bromo-4-(methoxymethoxy)phenyl)-7-(3-hydroxy-4-methoxyphenyl)heptan-3-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine / dichloromethane / 0 °C

2.1: potassium carbonate / acetone / 0 °C

3.1: water; lithium hydroxide / tetrahydrofuran

4.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / tetrahydrofuran

4.2: 20 °C

5.1: tetrahydrofuran; diethyl ether / 4 h / 20 °C

6.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 2 h / Reflux

7.1: palladium on activated charcoal; hydrogen / dichloromethane / 4 h / 20 °C

With 4-methyl-morpholine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; palladium on activated charcoal; water; hydrogen; bromine; potassium carbonate; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1016/j.bmcl.2011.11.025