9-(3'-methoxy-biphenyl-2-ylmethyl)-6-(4-nitro-benzylsulfanyl)-9H-purine

Base Information

Chemical Name:9-(3'-methoxy-biphenyl-2-ylmethyl)-6-(4-nitro-benzylsulfanyl)-9H-purine
CAS No.:791078-10-9
Molecular Formula:C₂₆H₂₁N₅O₃S
Molecular Weight:483.55
Hs Code.:

9-(3'-methoxy-biphenyl-2-ylmethyl)-6-(4-nitro-benzylsulfanyl)-9<i>H</i>-purine

Synonyms:9-(3'-methoxy-biphenyl-2-ylmethyl)-6-(4-nitro-benzylsulfanyl)-9H-purine

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Chemical Property of 9-(3'-methoxy-biphenyl-2-ylmethyl)-6-(4-nitro-benzylsulfanyl)-9H-purine

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Technology Process of 9-(3'-methoxy-biphenyl-2-ylmethyl)-6-(4-nitro-benzylsulfanyl)-9H-purine

There total 5 articles about 9-(3'-methoxy-biphenyl-2-ylmethyl)-6-(4-nitro-benzylsulfanyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 5434-26-4
6-[(4-nitrobenzyl)sulfanyl]-9H-purine

: 791078-03-0
2-(3-methoxyphenyl)benzyl bromide

: 791078-10-9
9-(3'-methoxy-biphenyl-2-ylmethyl)-6-(4-nitro-benzylsulfanyl)-9H-purine

Guidance literature:: 6-[(4-nitrobenzyl)sulfanyl]-9H-purine; With sodium hydride; In N,N-dimethyl-formamide; for 0.0833333h;

2-(3-methoxyphenyl)benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm049735v

Reference yield:

: 2398-37-0
3-methoxyphenyl bromide

: 791078-10-9
9-(3'-methoxy-biphenyl-2-ylmethyl)-6-(4-nitro-benzylsulfanyl)-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 74 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / 80 °C

2.1: NBS; benzoyl peroxide / CCl₄ / 40 h / 80 °C

3.1: NaH / dimethylformamide / 0.08 h

3.2: 37 percent / dimethylformamide / 16 h / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; dibenzoyl peroxide; In tetrachloromethane; ethanol; N,N-dimethyl-formamide; toluene; 1.1: Suzuki coupling;
DOI:10.1021/jm049735v

Reference yield:

: 135227-03-1
3-methoxy-2'-methyl-1,1'-biphenyl

: 791078-10-9
9-(3'-methoxy-biphenyl-2-ylmethyl)-6-(4-nitro-benzylsulfanyl)-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1.1: NBS; benzoyl peroxide / CCl₄ / 40 h / 80 °C

2.1: NaH / dimethylformamide / 0.08 h

2.2: 37 percent / dimethylformamide / 16 h / 20 °C

With N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049735v