4-(3-chloro-4-hydroxy-5-nitrophenoxy)-pyridine-2-carboxylic acid methylamide

Base Information

Chemical Name:4-(3-chloro-4-hydroxy-5-nitrophenoxy)-pyridine-2-carboxylic acid methylamide
CAS No.:952490-67-4
Molecular Formula:C₁₃H₁₀ClN₃O₅
Molecular Weight:323.692
Hs Code.:

Synonyms:4-(3-chloro-4-hydroxy-5-nitrophenoxy)-pyridine-2-carboxylic acid methylamide

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Chemical Property of 4-(3-chloro-4-hydroxy-5-nitrophenoxy)-pyridine-2-carboxylic acid methylamide

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Technology Process of 4-(3-chloro-4-hydroxy-5-nitrophenoxy)-pyridine-2-carboxylic acid methylamide

There total 5 articles about 4-(3-chloro-4-hydroxy-5-nitrophenoxy)-pyridine-2-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 952490-98-1
4-(3-chloro-4-hydroxyphenoxy)-pyridine-2-carboxylic acid methylamide

: 952490-67-4
4-(3-chloro-4-hydroxy-5-nitrophenoxy)-pyridine-2-carboxylic acid methylamide

Guidance literature:: With nitric acid; acetic acid; In water; at 20 ℃; for 18h;
DOI:10.1021/jm070034i

Reference yield:

: 952490-92-5
4-(4-(benzyloxy)-3-chlorophenoxy)-pyridine-2-carboxylic acid methylamide

: 952490-67-4
4-(3-chloro-4-hydroxy-5-nitrophenoxy)-pyridine-2-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / 20 h / Heating

2: HNO₃; acetic acid / H₂O / 18 h / 20 °C

With nitric acid; acetic acid; trifluoroacetic acid; In water;
DOI:10.1021/jm070034i

Reference yield:

: 66422-84-2
4-benzyloxy-3-chlorobenzaldehyde

: 952490-67-4
4-(3-chloro-4-hydroxy-5-nitrophenoxy)-pyridine-2-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: m-CPBA / CH₂Cl₂ / 120 h / 20 °C

1.2: 87 percent / NaOH / methanol / 1 h

2.1: NaH / dimethylformamide / 0.17 h / 20 °C

2.2: dimethylformamide / 8 h / 20 - 85 °C

3.1: TFA / 20 h / Heating

4.1: HNO₃; acetic acid / H₂O / 18 h / 20 °C

With nitric acid; sodium hydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm070034i