2-bromo-6-(3-methoxybenzyl)-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

Base Information

Chemical Name:2-bromo-6-(3-methoxybenzyl)-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one
CAS No.:1222839-26-0
Molecular Formula:C₁₇H₁₄BrN₃O₂S
Molecular Weight:404.287
Hs Code.:

Synonyms:2-bromo-6-(3-methoxybenzyl)-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

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Chemical Property of 2-bromo-6-(3-methoxybenzyl)-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

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Technology Process of 2-bromo-6-(3-methoxybenzyl)-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

There total 7 articles about 2-bromo-6-(3-methoxybenzyl)-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1221186-56-6
2-bromo-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

: 824-98-6
m-methoxybenzyl chloride

: 1222839-26-0
2-bromo-6-(3-methoxybenzyl)-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield:

: 1221186-56-6
2-bromo-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

: 874-98-6
1-bromomethyl-3-methoxybenzene

: 1222839-26-0
2-bromo-6-(3-methoxybenzyl)-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 100 ℃; for 12h;
DOI:10.1016/j.bmcl.2010.04.015

Reference yield:

: 4701-17-1
5-bromo-2-thiophencarboxaldehyde

: 1222839-26-0
2-bromo-6-(3-methoxybenzyl)-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium ethanolate / ethanol / 1.5 h / -10 - 0 °C

2.1: 5,5-dimethyl-1,3-cyclohexadiene / 0.17 h / 160 °C

3.1: trichlorophosphate / 1,2-dichloro-ethane / 0 - 85 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.2: 2 h / 0 - 20 °C

5.1: hydrazine hydrate / 2-methoxy-ethanol / 2 h / 110 °C

6.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With potassium tert-butylate; sodium ethanolate; sodium hydride; hydrazine hydrate; trichlorophosphate; In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; 2-methoxy-ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;