2-broMo-4,6-dihydro-4-Methyl-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one

Base Information

Chemical Name:2-broMo-4,6-dihydro-4-Methyl-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
CAS No.:1221186-56-6
Molecular Formula:C9H6BrN3OS
Molecular Weight:284.136
Hs Code.:
Mol file:1221186-56-6.mol

Synonyms:2-broMo-4,6-dihydro-4-Methyl-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one;2-bromo-4-methyl-4H-thieno[3,2-b]pyrrolo[3,2-d]pyridazinone;2-bromo-4-methyl-4H-thieno[3,2-b]pyrrole[3,2-d]pyridazinone;QC-8935;

Suppliers and Price of 2-broMo-4,6-dihydro-4-Methyl-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

AK Scientific
2-Bromo-4,6-dihydro-4-methyl-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
10g
$ 12929.00

Total 13 raw suppliers

Chemical Property of 2-broMo-4,6-dihydro-4-Methyl-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one

Chemical Property:

PKA:11.35±0.20(Predicted)
PSA：79.18000
Density:2.09±0.1 g/cm3(Predicted)
LogP:2.65110

Purity/Quality:

99%, ^*data from raw suppliers

2-Bromo-4,6-dihydro-4-methyl-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-broMo-4,6-dihydro-4-Methyl-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one

There total 5 articles about 2-broMo-4,6-dihydro-4-Methyl-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1221186-55-5
ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate

: 1221186-56-6
2-bromo-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

Guidance literature:: With hydrazine hydrate; In 2-methoxy-ethanol; for 3h; Inert atmosphere; Reflux;

Reference yield:

: 4701-17-1
5-bromo-2-thiophencarboxaldehyde

: 1221186-56-6
2-bromo-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium ethanolate / ethanol / 1.5 h / -10 - 0 °C

2.1: 5,5-dimethyl-1,3-cyclohexadiene / 0.17 h / 160 °C

3.1: trichlorophosphate / 1,2-dichloro-ethane / 0 - 85 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.2: 2 h / 0 - 20 °C

5.1: hydrazine hydrate / 2-methoxy-ethanol / 2 h / 110 °C

With sodium ethanolate; sodium hydride; hydrazine hydrate; trichlorophosphate; In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; 2-methoxy-ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1421933-23-4
ethyl (Z)-2-azido-3-(5-bromo-2-thienyl)prop-2-enoate

: 1221186-56-6
2-bromo-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 5,5-dimethyl-1,3-cyclohexadiene / 0.17 h / 160 °C

2.1: trichlorophosphate / 1,2-dichloro-ethane / 0 - 85 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 2 h / 0 - 20 °C

4.1: hydrazine hydrate / 2-methoxy-ethanol / 2 h / 110 °C

With sodium hydride; hydrazine hydrate; trichlorophosphate; In 5,5-dimethyl-1,3-cyclohexadiene; 2-methoxy-ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;