ethyl 2-<4-<<2-(tert-butoxycarbonylamino)ethyl>oxy>phenyl>-3-(7-cyano-2-naphthyl)propanoate

Base Information

Chemical Name:ethyl 2-<4-<<2-(tert-butoxycarbonylamino)ethyl>oxy>phenyl>-3-(7-cyano-2-naphthyl)propanoate
CAS No.:166319-64-8
Molecular Formula:C₂₉H₃₂N₂O₅
Molecular Weight:488.583
Hs Code.:

Synonyms:ethyl 2-<4-<<2-(tert-butoxycarbonylamino)ethyl>oxy>phenyl>-3-(7-cyano-2-naphthyl)propanoate

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Chemical Property of ethyl 2-<4-<<2-(tert-butoxycarbonylamino)ethyl>oxy>phenyl>-3-(7-cyano-2-naphthyl)propanoate

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Technology Process of ethyl 2-<4-<<2-(tert-butoxycarbonylamino)ethyl>oxy>phenyl>-3-(7-cyano-2-naphthyl)propanoate

There total 4 articles about ethyl 2-<4-<<2-(tert-butoxycarbonylamino)ethyl>oxy>phenyl>-3-(7-cyano-2-naphthyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (Z)-2-[4-(2-tert-Butoxycarbonylamino-ethoxy)-phenyl]-3-(7-cyano-naphthalen-2-yl)-acrylic acid ethyl ester

: 166319-64-8
ethyl 2-<4-<<2-(tert-butoxycarbonylamino)ethyl>oxy>phenyl>-3-(7-cyano-2-naphthyl)propanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 5h; under 760 Torr; Yield given;
DOI:10.1016/0223-5234(96)88248-1

Reference yield:

: 70080-54-5
4-hydroxy-alpha-oxobenzeneacetic acid ethyl ester

: 166319-64-8
ethyl 2-<4-<<2-(tert-butoxycarbonylamino)ethyl>oxy>phenyl>-3-(7-cyano-2-naphthyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 38.5 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 18 h / Ambient temperature

2: 1,8-diazabicyclo<5.4.0>undec-7-ene / tetrahydrofuran; ethanol / 18 h / Ambient temperature

3: H₂ / 5percent Pd/C / tetrahydrofuran / 5 h / 760 Torr

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/0223-5234(96)88248-1

Reference yield:

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

: 166319-64-8
ethyl 2-<4-<<2-(tert-butoxycarbonylamino)ethyl>oxy>phenyl>-3-(7-cyano-2-naphthyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 38.5 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 18 h / Ambient temperature

2: 1,8-diazabicyclo<5.4.0>undec-7-ene / tetrahydrofuran; ethanol / 18 h / Ambient temperature

3: H₂ / 5percent Pd/C / tetrahydrofuran / 5 h / 760 Torr

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/0223-5234(96)88248-1