FMOC-LYS(MCA)-OH

Base Information

• Chemical Name: FMOC-LYS(MCA)-OH
• CAS No.: 386213-32-7
• Molecular Formula: C33H32 N2 O8
• Molecular Weight: 584.626
• Hs Code.: 3204 90 00
• Mol file: 386213-32-7.mol

Synonyms:L-Lysine,N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-(9CI);

Chemical Property of FMOC-LYS(MCA)-OH

Chemical Property:

• Boiling Point: 885.2±65.0 °C(Predicted)
• PKA: 3.87±0.21(Predicted)
• PSA: 144.17000
• Density: 1.309±0.06 g/cm3(Predicted)
• LogP: 5.40430
• Storage Temp.: -15°C

Purity/Quality:

99%, ^*data from raw suppliers

Fmoc-Lys(Mca)-OH Novabiochem . CAS 386213-32-7, molar mass 584.62 g/mol., Novabiochem ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-LYS(MCA)-OH

There total 3 articles about FMOC-LYS(MCA)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-(benzotriazole-1-ylacetyl)-7-methoxycoumarin (1101836-32-1) + Fmoc-Lys-OH (105047-45-8) → (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamido)pentanoic acid (386213-32-7)

Guidance literature:

With triethylamine; In water; acetonitrile; at 20 ℃; for 0.333333h;

DOI:10.1039/b811693h

Reference yield: 51.0%

Nα-fluorenylmethoxycarbonyl-Nε-7-methoxycoumarin-4 acetyl-L-lysine tert-butyl ester → (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamido)pentanoic acid (386213-32-7)

Guidance literature:

With trifluoroacetic acid; at 0 - 30 ℃;

Reference yield:

Nα-fluorenylmethyloxycarbonyl-L-lysine-tert-butyl ester (940941-43-5) + 2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetic acid (62935-72-2) → (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamido)pentanoic acid (386213-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: diisopropyl-carbodiimide / N,N-dimethyl-formamide / -10 - 30 °C

2: trifluoroacetic acid / 0 - 30 °C

With trifluoroacetic acid; diisopropyl-carbodiimide; In N,N-dimethyl-formamide;

upstream raw materials:

4-(benzotriazole-1-ylacetyl)-7-methoxycoumarin

Fmoc-Lys-OH

Nα-fluorenylmethyloxycarbonyl-L-lysine-tert-butyl ester

2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetic acid

Downstream raw materials:

C₇₉H₁₀₈BrN₁₁O₁₈S

C₈₆H₁₂₆N₁₆O₃₈

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