(4-fluoro-3-hydroxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

Base Information

Chemical Name:(4-fluoro-3-hydroxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone
CAS No.:1357563-44-0
Molecular Formula:C₁₈H₁₁ClFNO₃
Molecular Weight:343.742
Hs Code.:

Synonyms:(4-fluoro-3-hydroxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

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Chemical Property of (4-fluoro-3-hydroxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

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Technology Process of (4-fluoro-3-hydroxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

There total 5 articles about (4-fluoro-3-hydroxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1357564-05-6
(4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

: 1357563-44-0
(4-fluoro-3-hydroxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

Guidance literature:: (4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone; With boron dimethyl-trifluoro sulphide; In dichloromethane; at 20 ℃;

With water; In dichloromethane;
DOI:10.1016/j.ejmech.2011.09.004

Reference yield:

: 1357563-99-5
(5-bromopyridin-2-yl)-(4-fluoro-3-methoxyphenyl)-methanol

: 1357563-44-0
(4-fluoro-3-hydroxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran / 60 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

3: boron dimethyl-trifluoro sulphide / dichloromethane / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron dimethyl-trifluoro sulphide; caesium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 2: Suzuki coupling;
DOI:10.1016/j.ejmech.2011.09.004

Reference yield:

: 31181-90-5
5-bromo-pyridine-2-carbaldehyde

: 1357563-44-0
(4-fluoro-3-hydroxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium / tetrahydrofuran / 2 h / 60 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

1.3: 20 °C

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran / 60 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

4.1: boron dimethyl-trifluoro sulphide / dichloromethane / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron dimethyl-trifluoro sulphide; caesium carbonate; magnesium; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 1.2: Grignard reaction / 3.1: Suzuki coupling;
DOI:10.1016/j.ejmech.2011.09.004