(4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

Base Information

Chemical Name:(4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone
CAS No.:1357564-05-6
Molecular Formula:C₁₉H₁₃ClFNO₃
Molecular Weight:357.769
Hs Code.:

Synonyms:(4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

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Chemical Property of (4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

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Technology Process of (4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

There total 4 articles about (4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 182344-13-4
(3-chloro-4-hydroxyphenyl)boronic acid

: 1357564-01-2
(5-bromopyridin-2-yl)-(4-fluoro-3-methoxyphenyl)-methanone

: 1357564-05-6
(4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.09.004

Reference yield:

: 1357563-99-5
(5-bromopyridin-2-yl)-(4-fluoro-3-methoxyphenyl)-methanol

: 1357564-05-6
(4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran / 60 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,2-dimethoxyethane; water; 2: Suzuki coupling;
DOI:10.1016/j.ejmech.2011.09.004

Reference yield:

: 31181-90-5
5-bromo-pyridine-2-carbaldehyde

: 1357564-05-6
(4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / 2 h / 60 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

1.3: 20 °C

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran / 60 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; magnesium; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.2: Grignard reaction / 3.1: Suzuki coupling;
DOI:10.1016/j.ejmech.2011.09.004