methyl 2-(tert-butoxy)-2-(2,6-dimethyl-4-(p-tolyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetate

Base Information

Chemical Name:methyl 2-(tert-butoxy)-2-(2,6-dimethyl-4-(p-tolyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetate
CAS No.:1449609-73-7
Molecular Formula:C₂₄H₃₂N₂O₃
Molecular Weight:396.53
Hs Code.:

Synonyms:methyl 2-(tert-butoxy)-2-(2,6-dimethyl-4-(p-tolyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetate

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Chemical Property of methyl 2-(tert-butoxy)-2-(2,6-dimethyl-4-(p-tolyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetate

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Technology Process of methyl 2-(tert-butoxy)-2-(2,6-dimethyl-4-(p-tolyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetate

There total 4 articles about methyl 2-(tert-butoxy)-2-(2,6-dimethyl-4-(p-tolyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: methyl 2-(tert-butoxy)-2-(2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetate dihydrochloride

: 1449609-73-7
methyl 2-(tert-butoxy)-2-(2,6-dimethyl-4-(p-tolyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; water; at 20 ℃; for 2h;

Reference yield:

: 1449609-67-9
benzyl 3-(2-methoxy-2-oxoacetyl)-2-methyl-4-(p-tolyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

: 1449609-73-7
methyl 2-(tert-butoxy)-2-(2,6-dimethyl-4-(p-tolyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / toluene / 2.5 h / -35 - -15 °C

2: perchloric acid / dichloromethane / 2.5 h / 20 °C / Sealed tube

3: hydrogenchloride; palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 3 h / 2585.81 Torr

4: acetic acid; sodium tris(acetoxy)borohydride / water; tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; perchloric acid; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

Reference yield:

: 1449609-69-1
benzyl 3-(1-(tert-butoxy)-2-methoxy-2-oxoethyl)-2-methyl-4-(p-tolyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

: 1449609-73-7
methyl 2-(tert-butoxy)-2-(2,6-dimethyl-4-(p-tolyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 3 h / 2585.81 Torr

2: acetic acid; sodium tris(acetoxy)borohydride / water; tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water;